Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine

Purpose

This study will assess analgesia after robotic lung surgery. Subjects will be randomized to receive wound infiltration and intercostal nerve block with either liposomal bupivacaine or bupivacaine/epinephrine + dexamethasone. Liposomal bupivacaine is a newer local anesthetic product and has not been compared to a combination of bupivacaine/epinephrine + dexamethasone in the context of pain control after robotic lung surgery.

Condition

  • Robotic Lung Surgery

Eligibility

Eligible Ages
Between 18 Years and 90 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • undergoing robotic wedge resection or lobectomy for lung mass(es)

Exclusion Criteria

  • emergency case - history of opiate abuse - chronic pain syndrome - intravenous drug use - chronic use of oral steroids - pregnancy - imprisonment - body weight lower than 70 kg - liver failure - uninsured patients - non-verbal patients or patients who are unable to rate their pain on a visual analogue pain scale - history of allergic reaction to any of the drugs used in the study: bupivacaine, liposomal bupivacaine, dexamethasone

Study Design

Phase
Phase 4
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Double (Participant, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Bupivacaine/epinephrine + dexamethasone
  • Drug: Intercostal nerve block and wound infiltration with bupivacaine/epinephrine + dexamethasone
    Intercostal nerve block and wound infiltration with liposomal bupivacaine during robotic lung resection surgery. 42 ml of 0.5% Bupivacaine/epinephrine with 8mg dexamethasone will be used.
Active Comparator
Liposomal bupivacaine
  • Drug: Intercostal nerve block and wound infiltration with liposomal bupivacaine
    Intercostal nerve block and wound infiltration with liposomal bupivacaine during robotic lung resection surgery. 266mg of liposomal bupivacaine with 24 ml of 0.5% bupivacaine will be used.

Recruiting Locations

Cooper University Hospital
Camden, New Jersey 08103
Contact:
Noud van Helmond, MD
856-968-7336
vanhelmond-noud@cooperhealth.edu

More Details

Status
Recruiting
Sponsor
The Cooper Health System

Study Contact

Noud van Helmond, MD
856-968-7336
vanhelmond-noud@cooperhealth.edu