Improving Glycemic Control With Electrical Stimulation

Purpose

Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55/15/30% CHO/PRO/FAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min/day, 3x/week) and randomized into placebo/control, NMES, resistance training combined with NMES (RT +NMES), or resistance training (RT) group (n=15 per group), followed by collection of post-intervention data. The control group will receive electrical stimulation up to sensory level, the NMES group will receive stimulation up to tolerable intensity to induce visible muscle contraction, the RT+ NMES will receive stimulation up to tolerable intensity during resistance training, and the RT group will only receive exercise training. Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.

Conditions

  • Obesity
  • Overweight
  • Insulin Resistance

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Overweight/Obese (BMI ≥25) - Sedentary Lifestyle: Physical Activity Level<1.4 - Less than 150min/week of structured Exercise

Exclusion Criteria

  • Use of anti-hypertensive, lipid-lowering or insulin sensitizing medications - Excessive alcohol, drug abuse, smoking - Pregnant Women - Unwilling to adhere to the study Intervention

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Prevention
Masking
Single (Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Placebo Comparator
Control 		Participants will receive stimulation only up to sensory level.
  • Device: Neuromuscular Electrical Stimulation (Sensory)
    Group will receive Electrical Stimulation up to sensory level
    Other names:
    • Control
Experimental
NMES 		Participants will receive stimulation up to maximum tolerable level.
  • Device: Neuromuscular Electrical Stimulation
    Group will receive Electrical Stimulation up to maximum tolerable level
    Other names:
    • NMES Group
Placebo Comparator
Resistance Training 		Participants will receive exercise training with stimulation up to sensory level.
  • Device: Neuromuscular Electrical Stimulation (Sensory)
    Group will receive Electrical Stimulation up to sensory level
    Other names:
    • Control
  • Other: Resistance Training
    Group will receive exercise training.
Experimental
Resistance Training + NMES 		Participants will receive exercise training with stimulation up to maximum tolerable intensity.
  • Device: Neuromuscular Electrical Stimulation
    Group will receive Electrical Stimulation up to maximum tolerable level
    Other names:
    • NMES Group
  • Other: Resistance Training
    Group will receive exercise training.

Recruiting Locations

University of Texas at El Paso
El Paso, Texas 79968
Contact:
Sudip R Bajpeyi, PhD
9157475461
sbajpeyi@utep.edu

More Details

Status
Recruiting
Sponsor
University of Texas, El Paso

Study Contact

Sudip Bajpeyi, PhD
9157475461
sbajpeyi@utep.edu