The Alaska Oculocardiac Reflex Study
Purpose
Observation study monitoring vital signs and anesthetic variables particularly heart rate during prospective, ocular manipulation and specifically uniform tension on extra ocular muscles during strabismus surgery. *IRB approval from 1992 covered in letter from then IRB chair Dr. Judith Whitcomb, Anchorage, Alaska (letter 10/2020).*
Conditions
- Bradycardia
- Strabismus
Eligibility
- Eligible Ages
- Between 1 Month and 100 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Patient scheduled for ocular manipulation and tension on extra ocular muscles and strabismus surgery
Exclusion Criteria
- anophthalmia
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| anticholinergic | Patients who receive anticholinergic medication before strabismus surgery |
|
| non-anticholinergic | Patients who do not received anticholinergic medication before strabismus surgery |
|
Recruiting Locations
Anchorage, Alaska 99508
More Details
- Status
- Recruiting
- Sponsor
- Alaska Blind Child Discovery
Detailed Description
Patients with ocular manipulation including those scheduled for strabismus surgery will have peri-operative variables monitored before, during and after uniform traction on extra ocular muscles (EOM). The oculocardiac reflex (OCR) will be elicited by quantified (200 gram, 10-second, square-wave) traction on Jameson muscle hook under insertion of an extra ocular muscle (EOM, rectus). Stable pre-tension heart rate, and greatest change heart rate will be recorded. Additional variables to be recorded: birthdate, gender, race, weight, iris color, pre-operative neurodevelopmental conditions, pre-operative medications, induction medications, expired carbon dioxide (CO2) levels, exhaled gas concentrations, anticholinergic medications, opioids, muscle relaxants, type of airway and the number of EOM operated.