Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Purpose

This study has two phases: Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers. Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Conditions

  • Alcohol Drinking
  • Binge Drinking
  • Blood Pressure
  • Alcohol Abstinence
  • Aging
  • Lifestyle Factors
  • Vasodilation
  • Behavioral Problem

Eligibility

Eligible Ages
Between 50 Years and 64 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink - Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr). - Subjects who can speak and understand English.

Exclusion Criteria

  • a history of diabetes, cardiovascular disease, liver, or renal disease - current or history of smoking and illicit drug use - blood pressure ≥160/100 mm Hg - other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol>230 mg/dl and/or LDL cholesterol>160 mg/dl) - active infection (in the past 2 months) - a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid) - unstable body weight (>5% change during the past 6 months) - regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week) - current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Prevention
Masking
Double (Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Exercise Group 		Binge drinkers who have been assigned to exercise group will receive baseline assessment, 8-week exercise training plus alcohol abstinence intervention, and post-intervention assessment.
  • Behavioral: Exercise Training
    Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.
  • Behavioral: Alcohol Abstinence Intervention
    Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
Active Comparator
Non-exercise Group 		Binge drinkers who have been assigned to non-exercise group will receive baseline assessment, 8-week alcohol abstinence intervention, and post-intervention assessment.
  • Behavioral: Alcohol Abstinence Intervention
    Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.
No Intervention
Alcohol abstainer/moderate drinker group 		Alcohol abstainer/moderate drinker will complete baseline assessment only and will not receive any intervention.

Recruiting Locations

University of Texas at Arlington
Arlington 4671240, Texas 4736286 76010
Contact:
Chueh-Lung Hwang, PhD, PT
817-272-9722
chuehlung.hwang@uta.edu

More Details

Status
Recruiting
Sponsor
The University of Texas at Arlington

Study Contact

Chueh-Lung Hwang, PhD
8172729722
chuehlung.hwang@uta.edu

Detailed Description

During phase 1, we will measure blood pressure, microvascular function, and sympathetic nerve activity (baseline assessment) in mid-life adult binge drinkers, alcohol abstainers, and moderate drinkers. Only mid-life adult binge drinkers will enter Phase 2 and be randomized to the exercise training group and non-exercise control group. After 8 weeks of intervention, we will re-measure blood pressure, microvascular function, and sympathetic nerve activity (post-intervention assessment) in mid-life adult binge drinkers.