Cerebrovascular Dysregulation in Chronic Kidney Disease

Purpose

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

Condition

  • Chronic Kidney Diseases

Eligibility

Eligible Ages
Between 30 Years and 75 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

• Individuals with chronic kidney disease stages III-IV.

Exclusion Criteria

  • Heart failure - Chronic obstructive pulmonary disease - Uncontrolled hypertension or hypotension - Pregnancy or plans to become pregnant - Inability to exercise on a stationary bicycle - Current participation in exercise more than 20 minutes twice per week

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Intervention Model Description
Participants will be assigned to one of two conditions:1) aerobic exercise training on a stationary bicycle, or 2) stretching and balance training.
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Exercise Training 		Participants will exercise 3 times a week on a stationary bicycle. Exercise intensity will begin at low levels (50% of maximal heart rate reserve) and increase as tolerated to a maximum of 80% of maximal heart rate reserve. Exercise time will progress from an initial 20 minutes per session to a maximum of 45 minutes per session.
  • Behavioral: Exercise
    Participants randomized to this arm will exercise on a stationary bicycle.
Placebo Comparator
Stretching 		Participants will undergo progressive whole body stretching and balance exercises. This type of low intensity exercise is designed not to increase heart rate but rather to improve joint mobility and the ability to perform activities of daily living. This will serve as the control group to the exercise group. The control group will come in for stretching sessions 3 times per week for 20-45 minutes.
  • Behavioral: Stretching
    Participants randomized to this arm will perform stretching and balance exercise.

Recruiting Locations

University of North Texas
Denton, Texas 76203
Contact:
Justin Sprick, PhD
940-565-2226
justin.sprick@unt.edu

More Details

Status
Recruiting
Sponsor
University of North Texas, Denton, TX

Study Contact

Justin Sprick, PhD
940-565-2226
justin.sprick@unt.edu

Detailed Description

Prior research has shown that CKD patients have an increased risk of stroke and that impairments in brain blood flow regulation predict stroke in other chronic disease states. This study will test whether exercise training can improve brain blood flow regulation via improved dynamic cerebral autoregulation and cerebrovascular carbon dioxide reactivity in CKD. Participants will undergo exercise training on a stationary bicycle, or stretching exercises, 3 times per week for 12 weeks.