Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

Purpose

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question: Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement? Does red light therapy improve forearm muscle endurance compared to a sham light exposure? Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Conditions

  • Health Care Utilization
  • Healthy Aging

Eligibility

Eligible Ages
Over 65 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion Criteria

  • Currently smoke - Have smoked within the last 6 months - Are taking taking supplements known to increase blood nitrate levels - Have a known kidney disease - Have a known liver disease - Have a known thyroid condition - Have a known gastritis condition - Are taking medications that are known to cause complications with nitrate supplementation - Have known or reported joint pain within the dominant hand

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Basic Science
Masking
Single (Participant)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Beet-root juice plus red-light therapy
  • Dietary Supplement: Beet-root juice
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.
    Other names:
    • Beet it Sport
  • Radiation: red-light therapy
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.
    Other names:
    • MitoMIN
Sham Comparator
Beet-root juice plus sham light therapy
  • Dietary Supplement: Beet-root juice
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.
    Other names:
    • Beet it Sport
  • Radiation: sham light
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.
Placebo Comparator
Placebo plus red-light therapy
  • Radiation: red-light therapy
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.
    Other names:
    • MitoMIN
  • Dietary Supplement: Placebo
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.
Active Comparator
Placebo plus sham light therapy
  • Dietary Supplement: Placebo
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.
  • Radiation: sham light
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Recruiting Locations

Wake Forest Univesity
Winston-Salem, North Carolina 27106
Contact:
Andrew D Wells, Ph.D.
336-758-5837
wellsa@wfu.edu

More Details

Status
Recruiting
Sponsor
Wake Forest University

Study Contact

Andrew D Wells, Ph.D.
(336) 758-5837
wellsa@wfu.edu