Natural History of Inflammatory Muscle Diseases
Purpose
Objective: To collect information and biospecimens (such as blood, muscle, and skin samples) that will be used to research causes and treatments of inflammatory muscle diseases. Eligibility: People aged 2 years and older with suspected or confirmed inflammatory muscle disease. Healthy volunteers aged 18 years and older are also needed. Design: Participants will have at least 1 clinic visit. Each visit will last 4 to 8 hours. Some may return for additional visits. All participants will undergo these procedures (unless they are unable to): - Physical exam, including blood and urine tests. - Magnetic resonance imaging (MRI) scan of the thigh. Participants will lie still on a table with padding around 1 thigh. The table will slide into a tube. The scan will last for approximately 40 minutes. Some procedures are optional: - Muscle biopsy: An area of skin will be numbed. A quarter-inch cut will be made. Several pieces of muscle tissue, about the size of grains of rice, will be removed. - Skin biopsy: An area of skin will be numbed. A piece of skin about a quarter inch in diameter will be removed. - Lymph node biopsy: A small sample of fluid or tissue from a lymph node will taken to check for infection. - Genetic testing. Some of the samples collected may be used for genetic testing.
Condition
- Inflammation In Skeletal Muscle
Eligibility
- Eligible Ages
- Between 2 Years and 120 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Ability of subject, or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent and/or assent document. 2a. Patients are adults and minors of age 2 or older, with possible inflammatory myopathy (suspected or confirmed) OR 2b. Healthy volunteers will be adults aged 18 or older.
Exclusion Criteria
- Unwilling to participate in research studies or to provide research samples or data.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Healthy Volunteers | 18 years old and up | |
| Patients | greater than 2 years old |
Recruiting Locations
Bethesda, Maryland 20892
More Details
- Status
- Recruiting
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Detailed Description
Study Description: This is an observational study to characterize the different types of inflammatory myopathies, understand their etiology, pathogenesis, prognosis, and response to different treatments. Objectives: Primary objective: Define the different types of inflammatory muscle diseases, their etiology, pathogenesis, prognostic factors, and response to different treatments. Secondary objectives: Study different diagnostic modalities that may help to diagnose and monitor the evolution of the disease in patients with myositis. Endpoints: Primary endpoint: Severity of muscle, skin, pulmonary, and joint involvement. Study of the immune dysregulation, transcriptomic changes, and genetic modifications in patients with inflammatory muscle diseases. Secondary endpoints: Utility of standard of care laboratory, radiologic, electrophysiologic, and clinical studies to diagnose and monitor the evolution of the disease in patients with myositis.