Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma
Purpose
Multiple myeloma (MM) is a cancer of the blood's plasma cells. The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections, weaker bones, and kidney failure. Treatments are available, but MM can come back (relapsed) or may not get better (refractory) with treatment. This is a study to determine change in disease symptoms of etentamig compared to standard available therapies in adult participants with relapsed/refractory (R/R) MM. Etentamig is an investigational drug being developed for the treatment of R/R MM. This study is broken into 2 Arms; Arm A and Arm B. In Arm A, participants will receive etentamig as a monotherapy. In Arm B, participants will receive the standard available therapy (SAT) identified by the Investigator during screening, in accordance with the local (or applicable) approved label, package insert, summary of product characteristics, and/or the institutional guidelines, as applicable. Around 380 adult participants with relapsed/refractory multiple myeloma will be enrolled at approximately 140 sites across the world. In Arm A participants will receive etentamig as an infusion into the vein in 28 day cycles, during the 3.5 year study duration. In Arm B, participants will receive the SAT identified by the Investigator during screening, in accordance with the local (or applicable) approved label, package insert, summary of product characteristics, and/or the institutional guidelines, as applicable, during the 3.5 year study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and questionnaires.
Condition
- Multiple Myeloma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Eastern Cooperative Oncology Group (ECOG) performance of <= 2. - Diagnosis of relapsed/refractory (R/R) multiple myeloma (MM) during or after the participant's last treatment as stated in the protocol. - Must have measurable disease with at least 1 of the following assessed within 28 days of enrollment: - Serum M-protein >= 0.5 g/dL (>= 5 g/L). - Urine M-protein >= 200 mg/24 hours. - In participants without measurable serum or urine M protein, serum free light chain (FLC) >= 100 mg/L (10 mg/dL) (involved light chain)and an abnormal serum kappa lambda ratio. - Must have received at least 2 or more lines of therapy, including a proteasome inhibitor (PI), an immunomodulatory imide (IMiD), and an anti-CD38 monoclonal antibody (mAb). -- US and Puerto Rico only: Participant must have received at least 1 or more line of therapy, including exposure to a PI, an IMiD, and an anti-CD38 mAb. - Must be eligible to receive the Investigator's choice standard available therapy (SAT) based on approved prescribing information, previous MM treatment history, and institutional guidelines.
Exclusion Criteria
- Clinically significant (per Investigator's judgment) drug or alcohol abuse within the last 6 months. - Clinically significant conditions such as but not limited to the following: neurologic, psychiatric, endocrine, metabolic, immunologic, cardiovascular, pulmonary, or hepatic disease within the last 6 months that would adversely affect the participant's participation in the study. - Central nervous system involvement of MM. - Has received B-cell maturation antigen (BCMA)-targeted therapy.
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Etentamig |
Participants will receive etentamig as a monotherapy. |
|
|
Experimental Standard Available Therapy (SAT) |
Participants will receive SAT, in accordance with the local (or applicable) approved label, package insert, summary of product characteristics, and/or the institutional guidelines, as applicable. SAT choices are carfilzomib + dexamethasone (Kd), elotuzumab + pomalidomide + dexamethasone (EloPd), selinexor + bortezomib + dexamethasone (SVd). |
|
Recruiting Locations
Birmingham, Alabama 35233
Phoenix, Arizona 85054
Fullerton, California 92835
Loma Linda, California 92357
Los Angeles, California 90048
Lone Tree, Colorado 80124
Jacksonville, Florida 32224
Jacksonville, Florida 32256
Site Coordinator
904-538-4488
Atlanta, Georgia 30322
Chicago, Illinois 60607
Elmhurst, Illinois 60126
Baton Rouge, Louisiana 70808
Bethesda, Maryland 20817
Boston, Massachusetts 02215
Boston, Massachusetts 02215
Ann Arbor, Michigan 48109-1276
Detroit, Michigan 48201
Lansing, Michigan 48912
Rochester, Minnesota 55905-0001
Omaha, Nebraska 68130
Bay Shore, New York 11706
The Bronx, New York 10469
Chapel Hill, North Carolina 27514
Charlotte, North Carolina 28204
Cleveland, Ohio 44195
Portland, Oregon 97239
Charleston, South Carolina 29425
Memphis, Tennessee 38103
Memphis, Tennessee 38120
Memphis, Tennessee 38120
Site Coordinator
9016830055
Nashville, Tennessee 37232-0011
Houston, Texas 77030
Tyler, Texas 75702
Fairfax, Virginia 22031
Richmond, Virginia 23298
Tacoma, Washington 98405
More Details
- Status
- Recruiting
- Sponsor
- AbbVie