Oxygenation in Vascular Lesions of the Colon

Purpose

The goal of this clinical trial is to evaluate oxygenation in the colon in people with acquired vascular abnormalities in the proximal colon.

Condition

  • Vascular Lesion

Eligibility

Eligible Ages
Between 18 Years and 89 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Undergo standard of care colonoscopy - People with a history of vascular lesions of the colon - People with healthy colon - 18 - 89 years of age

Exclusion Criteria

  • Age < 18 years - Age > 90 years - People with ulcerations in at ascending colon opposite the ileocecal valve - Previous colon surgery

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Screening
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Vascular abnormality group 		People with acquired vascular abnormalities in the proximal colon
  • Other: Oxygen saturation
    Measure oxygen levels in 5 proximal colon mucosa locations.
Active Comparator
Control group 		People with healthy colon
  • Other: Oxygen saturation
    Measure oxygen levels in 5 proximal colon mucosa locations.

Recruiting Locations

University of Chicago
Chicago, Illinois 60637
Contact:
Joel Pekow, MD
(773) 834-8632
jpekow@bsd.uchicago.edu

More Details

Status
Recruiting
Sponsor
University of Chicago

Study Contact

Joel Pekow, MD
(773) 834-8632
jpekow@bsd.uchicago.edu

Detailed Description

The etiology of acquired vascular abnormalities of the large bowel (i.e. angiodysplasia, AVM, hemangiomas of the cecum. etc.) are unknown. These lesions typical appear as ectatic, dilated, and tortuous blood vessels within the submucosa and mucosa of the GI tract. In some patients they are the cause of acute large volume bleeding or a slower chronic bleed that manifests as chronic iron deficiency anemia. These lesions are more common in older individuals and those with underlying cardiac, pulmonary, and renal disease. As such, it is hypothesized that these lesions may result from chronic hypoxia. This study aims to evaluate oxygenation of the colon in people with acquired vascular abnormalities in the proximal colon compared to healthy controls.