Risk of Nerve Damage After Administration of Local Anesthesia

Purpose

This research aims to evaluate of the risk of nerve damage following the administration of articaine 4% and lidocaine 2% for Inferior Alveolar nerve Block (IANB). A Randomized Controlled Clinical Trial will be conducted where the patient will be randomly assigned to one the two groups; articaine 4% and Lidocaine 2%. The type of LA will be concealed to the operator, investigators and assessors. The patients will be monitored for any aigns of nerve parathesia for 3 months after the procedure.

Condition

  • Inferior Alveolar Nerve Injuries

Eligibility

Eligible Ages
Between 18 Years and 55 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Patients with age between 18-55 years old - Patients need IANB - healthy patient

Exclusion Criteria

  • medical conditions - allergies - medications - pregnancy and breastfeeding - inability to provide informed consent - specific dental or medical history.

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Articaine 		Inferior Alveolar Nerve block using Articaine 4% with 1:200,000 epinephrine local anesthetic
  • Drug: 4% Articaine with 1:200,000 epinephrine
    Inferior Alveolar Nerve Block with 4% articaine
Active Comparator
Lidocaine 		Inferior Alveolar Nerve block using 2% lidocaine with 1:100,000 epinephrine local anesthetic
  • Drug: 2% lidocaine with 1:100,000 epinephrine
    Inferior Alveolar Nerve Block with 2% lidocaine

Recruiting Locations

Cleveland Dental Institute
Akron, Ohio 44703
Contact:
Waleed Elmallah, PhD
216-333-6695
w.elmallah@cdiohio.org

More Details

Status
Recruiting
Sponsor
Cleveland Dental Institute

Study Contact

Pablo R Velazquez, Resident
7546108595
p.velazquez@cdiohio.org