Eating Disorders Genetics Initiative 2

Purpose

The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

Conditions

  • Anorexia Nervosa
  • Bulimia Nervosa
  • Binge-Eating Disorder
  • Avoidant Restrictive Food Intake Disorder

Eligibility

Eligible Ages
Between 12 Years and 99 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms - Age 12-99 years, depending on country. (US enrollment age is 18-99)

Exclusion Criteria

  • History of subthreshold disordered eating behaviors.

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Other

Arm Groups

ArmDescriptionAssigned Intervention
Anorexia nervosa Individuals with a self-reported lifetime history of anorexia nervosa.
  • Other: Eating disorder diagnosis group
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.
Bulimia nervosa Individuals with a self-reported lifetime history of bulimia nervosa.
  • Other: Eating disorder diagnosis group
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.
Binge-eating disorder Individuals with a self-reported lifetime history of binge-eating disorder.
  • Other: Eating disorder diagnosis group
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.
ARFID Individuals with a self-reported lifetime history of avoidant restrictive food intake disorder.
  • Other: Eating disorder diagnosis group
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.
Control Individuals with no history of disordered eating behaviors or symptoms
  • Other: Eating disorder diagnosis group
    This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.

Recruiting Locations

University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27599-7160
Contact:
Laura M Thornton, PhD
804-690-3079
laura_thornton@med.unc.edu

More Details

Status
Recruiting
Sponsor
University of North Carolina, Chapel Hill

Study Contact

Laura M Thornton, PhD
804-690-3079
laura_thornton@med.unc.edu