Loss of Y Chromosome in Aortic Stenosis
Purpose
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
Condition
- Aortic Stenosis
Eligibility
- Eligible Ages
- Over 40 Years
- Eligible Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Aortic stenosis (valve area <1.5cm2)
Exclusion Criteria
- Bicuspid aortic valve - History of radiation to chest - Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis - Active cancer
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Control
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Males with aortic stenosis | Males with mild or greater aortic stenosis (aortic valve area <1.5 cm2) due to calcific non-congenital aortic stenosis. |
|
| Control males without aortic stenosis | Males without any diagnosis for aortic stenosis (matched for aortic stenosis group). |
|
Recruiting Locations
University of Virginia
Charlottesville, Virginia 22903
Charlottesville, Virginia 22903
More Details
- Status
- Recruiting
- Sponsor
- University of Virginia