Study of Oral Fluid Testing Approach

Purpose

The purpose of this study is to identify and evaluate oral fluid testing as a biologic measure of cannabis use days that can be assessed remotely. The researchers will conduct this fully virtual study among a community sample of 200 individuals aged 18-30 years who have used cannabis at least 1 time per week on average in the past 30 days. Participants will complete oral fluid (saliva) tests, urine tests, and Timeline Follow-back interviews (self-report) that indicate their recent cannabis use (delta-9-THC). Participants will present for 3 virtual study visits across ~3-4 weeks and be asked to complete activities in between: Study Visit 1 (Day 0; informed consent, baseline survey, TLFB interview), Study Visit 2 (~Day 7; TLFB interview, urine testing), 6 days of at-home videorecorded oral fluid testing, Study Visit 3 (~Day 21; TLFB interview, urine test, oral fluid test, survey, interview).

Conditions

  • Cannabis Use
  • Cannabis Intoxication
  • Cannabis Use Disorder

Eligibility

Eligible Ages
Between 18 Years and 30 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age 18 to 30 years - Cannabis use on >=1x/week in the past 30 days - Ownership of a portable device that is capable of videoconference and videorecording (i.e., smartphone, tablet computer, or laptop computer) - Ability to read and speak English - Availability for duration of the study (3-4 weeks). - To proceed to oral fluid testing, positive result for urinary TCH-COOH

Exclusion Criteria

• Inability/unwillingness to provide contact information

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
Prospective community sample Community sample of 200 younger adults aged 18-30 years who have used cannabis in the past 30 days, report use frequency of ≥1x/week, and have a positive test for urinary 11-nor-9-carboxy-delta-9-tetrocannabinol (THC-COOH) at baseline
  • Other: Biologic testing for THC
    Participants will be asked to complete at-home urine test(s) and a series of oral fluid tests.

Recruiting Locations

Boston Children's Hospital
Boston, Massachusetts 02115
Contact:
Lydia A. Shrier, MD, MPH
617-355-8306
lydia.shrier@childrens.harvard.edu

More Details

Status
Recruiting
Sponsor
Boston Children's Hospital

Study Contact

Lydia A Shrier, MD, MPH
(617) 355-8306
lydia.shrier@childrens.harvard.edu