Transcranial Magnetic Stimulation in Misophonia
Purpose
The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.
Condition
- Misophonia
Eligibility
- Eligible Ages
- Between 18 Years and 55 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear. - Must be between the ages of 18 - 55. - Must be fluent in English since the study's instructions, surveys, and tasks will be in English.
Exclusion Criteria
- Epilepsy or previous episode of convulsion or seizure. - Previous episode of fainting spell or syncope. - Head trauma. - Hearing problems. - Cochlear implant. - Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.). - Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS). - Presence of cardiac pacemaker or intracardiac lines. - Presence of medication infusion device. - Use of pro-convulsant or epileptogenic medications. - Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children. - Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children. - Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Intervention Model Description
- Participants will undergo two sessions of TMS, one inhibitory and another excitatory. The immediate changes resulting from both will be measured and compared.
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Masking Description
- This is a TMS study. Only the technician administering TMS will be unblinded. All parties will be blinded till the end of the study. The technician is not involved in the data analysis.
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Inhibitory-Excitatory (IE) then Excitatory-Inhibitory (EI) |
Participants in this group will receive an inhibitory TMS in the first session and an excitatory TMS in the second session. The two sessions will be separated by 72 hours. |
|
|
Active Comparator Excitatory-Inhibitory (EI) then Inhibitory-Excitatory (IE) |
Participants in this group will receive an excitatory TMS in the first session and an inhibitory TMS in the second session. The two sessions will be separated by 72 hours. |
|
Recruiting Locations
More Details
- Status
- Recruiting
- Sponsor
- Icahn School of Medicine at Mount Sinai