Personalized Accelerated TMS for High-Risk Adolescent Depression

Purpose

The goal of this clinical trial is to learn if a fast-acting brain stimulation treatment called transcranial magnetic stimulation (TMS) can help people with depression and suicidal thoughts. The treatment is non-invasive (does not involve surgery or medications), is given over 5 days, and uses brain imaging (MRI) to guide which part of the brain to target. This study tests whether this treatment is a helpful and practical option for adolescents and young adults who are depressed and have suicidal thoughts. We want to see if: 1. This treatment is feasible and acceptable to patients 2. It can reduce depression and suicidal thoughts 3. It can lower the chance of going to the hospital 4. It affects daily functioning (school, work, relationships) All participants will undergo 5-days of TMS treatment and complete MRI brain scans before and after treatment. They will return for check-ups after 1 week and 4 weeks.

Conditions

  • Major Depressive Disorder (MDD)
  • Suicidal Ideation

Eligibility

Eligible Ages
Between 15 Years and 25 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • English speaking - Able to provide informed consent - 15-25 years old - Discharged within the past week from the ED for chief complaint of SI OR recently admitted in urgent health care setting or seen in outpatient clinic for depression-related suicidal ideation - Meets MDD criteria per the Mini International Neuropsychiatric Interview (MINI)

Exclusion Criteria

  • Unable to consent (due to medical condition, psychosis, substance use, etc) - Use of benzodiazepines or medications that would interfere with TMS treatment as per PI discretion - Active substance use or severe substance use that in the opinion of the PI would interfere with study participation - Untreated, active psychosis - Female patient who is breastfeeding, pregnant or who is planning a pregnancy during the study - Participation in any clinical study with exposure to any investigational treatment or product within the previous 30 days, or plan on concurrent participation in other studies - Contraindications to receiving TMS and/or MRI as determined by screening questionnaires

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
TMS
  • Device: TMS
    The protocol involves delivering sessions of intermittent theta burst stimulation (iTBS) of 60 cycles of 10 bursts of three pulses at 50 Hz were delivered in 2-second trains (5 Hz) with an 8-second intertrain interval. Stimulation sessions will be delivered hourly. Ten sessions will be applied per day (18,000 pulses/day) for 5 consecutive days (90,000 pulses in total). Stimulation will be delivered at 90% resting motor threshold (rMT) adjusted for cortical depth. MR brain imaging will be used with the Localite Neuronavigation System (Localite GmbH, Sankt Augustin, Germany) to position the TMS coil over the individualized stimulation target.

Recruiting Locations

UC Davis Medical Center
Sacramento 5389489, California 5332921 95817
Contact:
Se Ri Bae, MD
916-244-0832
sebae@health.ucdavis.edu

More Details

Status
Recruiting
Sponsor
University of California, Davis

Study Contact

Se Ri (Sally) Bae, MD
213-340-4006
sebae@ucdavis.edu