An International Observational Study of Adults With Acute Infection
Purpose
Prospective, longitudinal studies of people with acute infections are essential to understand risk factors, clinical manifestations, pathobiology, and management strategies. Observational studies can provide data necessary to select interventions and strategies for testing in clinical trials and to develop key design features of trials. Observational studies can be particularly important for establishing an early knowledge base after emergence of a new pathogen, as illustrated by the recent emergence of influenza A (H1N1), SARS-CoV-2, and Mpox. This observational study protocol describes collection of data and biospecimens from sites across the world for characterizing acute infections in hospitalized patients. The protocol is designed to study respiratory infections, infections outside the respiratory tract, established infectious diseases, and emerging infectious diseases. Data generated in this study will be used to efficiently characterize acute infectious diseases and plan future clinical trials.
Condition
- Infectious Disease
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age ≥18 years old - Admitted to hospital (or in an emergency department with anticipated hospital admission) for the management of a suspected or confirmed acute infectious disease. - Onset of symptoms of an infectious disease within the past 30 days. - Informed consent for study participation by the participant or a surrogate decision maker if the participant lacks capacity for consent.
Exclusion Criteria
- Current imprisonment (this does not include quarantine for an infectious disease). - Patient undergoing comfort care measures only such that treatment focuses on end- of-life symptom management over prolongation of life. - Expected inability or unwillingness to participate in study procedures. - In the opinion of the investigator, participation in the study is not in the best interest of the patient.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Study group | The study population includes adult patients admitted to a hospital with a suspected or confirmed acute infection. |
|
Recruiting Locations
Tucson, Arizona 85719
Palo Alto, California 94305
San Francisco, California 94143
Orlando, Florida 32827
Chicago, Illinois 60612
Kansas City, Kansas 66160
Rochester, Minnesota 55905
Omaha, Nebraska 68198-5400
New York, New York 10016
New York, New York 11234
Durham, North Carolina 27710
Winston-Salem, North Carolina 27157
Cleveland, Ohio 44195
Nashville, Tennessee 37232
Dallas, Texas 75390
Houston, Texas 77030-4211
Murray, Utah 84107
Morgantown, West Virginia 26506
More Details
- Status
- Recruiting
- Sponsor
- University of Minnesota