Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Purpose

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Conditions

  • CBD
  • Cannabidiol
  • Stress
  • Acute Stress Reaction

Eligibility

Eligible Ages
Between 21 Years and 70 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Adults who are relatively healthy and aged 21-70 years. - Must keep a normal sleep schedule (sleep during nighttime, awake during daytime). - Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria

  • Participated in previous acute stress studies that included a similar stress induction. - Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100). - Self-reported current pregnancy. - Self-reported current use of illicit substances (other than cannabis). - Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.) - Students of the principal researcher

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Intervention Model Description
Single group assignment; all participants experience baseline rest, acute stress tasks, and recovery rest.
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Experimental group 		Participants will include CBD users and non users
  • Other: Stress Intervention
    Experimental Stress: Behavioral induction of acute psychosocial and physiological stress. First, participants will be provided with a speech topic and given 4 minutes to prepare a speech that they subsequently deliver in front of evaluators and a video recorder. Then, participants will complete a mental arithmetic task in front of the evaluators for 8 minutes. Then, participants will complete a cold pressor task in which they submerge their hand in ice water for 90 seconds.

Recruiting Locations

University of Minnesota
Minneapolis, Minnesota 55455
Contact:
Stress and Resilience Research Labs
218-726-8623
umdbml@d.umn.edu

More Details

Status
Recruiting
Sponsor
University of Minnesota

Study Contact

Stress and Resilience Research Labs
2187268623
umdbml@d.umn.edu