Combined tDCS and Cognitive Training as an Adjunctive Treatment in Opioid Use Disorder

Purpose

The overall goal of this study is to investigate the added benefit of a neuromodulation intervention in individuals taking medication for treatment for Opioid Use Disorder(OUD).

Condition

  • Opioid Use Disorder

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Ability to provide consent and comply with study procedures - Diagnostic and Statistical Manual of Mental Disorders criteria for OUD - Undergoing medication treatment for OUD. Participants may have current comorbid drug use, but primary diagnosis must be OUD - Intention to remain in the study until intervention completion.

Exclusion Criteria

  • Any medical condition with neurological sequelae - Head injury resulting in skull fracture or loss of consciousness of >30 minutes - Any tDCS or MRI contraindication (tDCS: history of seizures, metallic cranial plates/screws or implanted device, history of eczema on scalp. MRI: unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, or claustrophobia) - Any psychotic disorder (participants with other treated and stable psychiatric disorders will be included) - Presence of a condition that would render study measures impossible to administer or interpret - Age younger than 18 - Primary current substance use disorder on a substance other than opioids except for caffeine or nicotine - In treatment instead of jail - Pregnancy - Disrespectful behavior towards the investigators and staff.

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
tDCS 		All intervention sessions will use the Soterix Mini-CT Remote tDCS device
  • Device: Transcranial Direct Current Stimulation (tDCS)
    We will deliver 2-mA tDCS current intensity during a 30 minute stimulation period (including a 30-second ramp-up and 30-second ramp-down period) to the dorsolateral prefrontal cortex. Electrodes will be fixed on marked locations based on the 10-20 EEG system. Anodal stimulating electrode will be over the left DLPFC (F3) and cathodal electrode over the right DLPFC (F4).

Recruiting Locations

University of Minnesota
Minneapolis, Minnesota 55455
Contact:
Calvin Cahill
952-444-0137
cahil138@umn.edu

More Details

Status
Recruiting
Sponsor
University of Minnesota

Study Contact

Calvin Cahill
952-444-0137
cahil138@umn.edu