Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

Purpose

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Conditions

  • Cigarette Smoking-Related Carcinoma
  • E-Cig Use

Eligibility

Eligible Ages
Between 18 Years and 25 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Young adult (18-25 years old). - Ability to read and write in English. - Participants must fall into one of the following groups (based on self-report): - Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month. - Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products. - E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly. - No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit). - Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion Criteria

  • Individuals under the age of 18 or over the age of 25. - Currently pregnant or breastfeeding (female participants). - Unwilling or unable to follow protocol requirements

Study Design

Phase
Study Type
Observational
Observational Model
Case-Control
Time Perspective
Cross-Sectional

Arm Groups

ArmDescriptionAssigned Intervention
E-cigarette consumers Predominant e-cigarette consumers
  • Other: Effectiveness of different recruitment approaches
    Subjects will asked which type of recruitment material they've seen when completing the screening survey
  • Other: Choice of study completion locations
    subjects will choose location when coordinator calls to schedule appointment
  • Other: E-cigarette dependence Scale
    A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.
Cannabis consumers Predominant cannabis consumers
  • Other: Effectiveness of different recruitment approaches
    Subjects will asked which type of recruitment material they've seen when completing the screening survey
  • Other: Choice of study completion locations
    subjects will choose location when coordinator calls to schedule appointment
  • Other: Cannabis Engagement Assessment
    Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.
e-cigarette -cannabis coconsumers Consumers who use both e-cigarettes and cannabis .
  • Other: Effectiveness of different recruitment approaches
    Subjects will asked which type of recruitment material they've seen when completing the screening survey
  • Other: Choice of study completion locations
    subjects will choose location when coordinator calls to schedule appointment
  • Other: Cannabis Engagement Assessment
    Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.
  • Other: E-cigarette dependence Scale
    A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.

Recruiting Locations

Roswell Park Comprehensive Cancer Center
Buffalo, New York 14263
Contact:
ASK RPCI
877-275-7724

More Details

Status
Recruiting
Sponsor
Roswell Park Cancer Institute

Study Contact

ASK RPCI
1-800-767-9355
askroswell@roswellpark.org

Detailed Description

PRIMARY OBJECTIVE: I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.