Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

Purpose

The main purpose of this study is to assess the safety and tolerability of AZD0516 as monotherapy and/or in combination with other anti-cancer agents for treatment of metastatic prostate cancer.

Condition

  • Metastatic Prostate Cancer

Eligibility

Eligible Ages
Between 18 Years and 130 Years
Eligible Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Histologically or cytologically confirmed diagnosis of metastatic adenocarcinoma of the prostate. Focal high grade neuroendocrine features are permitted. - Measurable PSA ≥ 1 μg/L (≥ 1 ng/mL). - Surgically or medically castrated with serum testosterone levels ≤ 50 ng/dL (≤ 1.75 nmol/L) within ≤ 28 days before treatment allocation. Ongoing androgen deprivation therapy (ADT) with a gonadotropin releasing hormone (GnRH) modulator for participants who have not undergone bilateral orchiectomy must be initiated at least 2 weeks prior to consent and must continue throughout the study. - Eastern cooperative oncology group (ECOG) performance status of 0 or 1. - Adequate organ and marrow function in the absence of blood transfusion or growth factor support (within 21 days prior to the scheduled first dose of study intervention). - Provision of baseline archival or newly obtained formalin-fixed paraffin-embedded (FFPE) tumour sample is mandatory. - Documented current evidence of metastatic prostate cancer - Life expectancy of at least 12 weeks in the opinion of the investigator - Documented mCRPC progression at screening as assessed by the investigator with at least one of the following criteria: 1. PSA progression defined by a minimum of 3 rising PSA levels with an interval of ≥ 1 week between each determination. The PSA value at the screening visit should be ≥ 1 μg/L (1 ng/mL). 2. Radiographic disease progression in soft tissue based on response evaluation criteria in solid tumors (RECIST) v1.1 criteria with or without PSA progression as per prostate cancer working group 3 (PCWG3). 3. Radiographic disease progression in bone defined as the appearance of 2 or more new bone lesions on a bone scan as per PCWG3 with or without PSA progression. Main

Exclusion Criteria

  • Cancer related spinal cord compression, or brain metastases unless asymptomatic, treated and stable and not requiring continuous corticosteroids at a dose of > 10 mg prednisone/day or equivalent for at least 4 weeks prior to study enrolment. - History of leptomeningeal carcinomatosis. - Unresolved toxicities of Grade ≥ 2 (National Cancer Institute Common Terminology Criteria for Adverse Events v5.0) from prior therapy (excluding vitiligo, alopecia, and endocrine disorders that are controlled with replacement hormone therapy). - Uncontrolled intercurrent illness within the last 12 months. - Cardiovascular disorder (History of arrhythmia, uncontrolled hypertension, symptomatic hypotension, history of brain perfusion problems, symptomatic heart failure, prior or current cardiomyopathy, severe valvular heart disease) - History of malignancy - History of non-infectious interstitial lung disease (ILD)/pneumonitis - Active infection exclusions, including tuberculosis and infections with Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) or Human Immunodeficiency Virus (HIV). - Any known predisposition to bleeding - Clinically severe pulmonary compromise - Participants with Myelodysplastic syndrome (MDS)/Acute Myeloid Leukemia (AML) or with features suggestive of MDS/AML. - Previous treatment with a STEAP2 targeting modality, chemotherapeutic agent that inhibits topoisomerase activity or metabolic enzymes.

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Sequential Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm 1: AZD0516 monotherapy 		Participants with mCRPC will receive AZD0516 monotherapy.
  • Drug: AZD0516
    AZD0516 will be administered via intravenous infusion.
Experimental
Arm 2: AZD0516 + AZD9574 		Participants with mCRPC will receive AZD0516 in combination with AZD9574.
  • Drug: AZD0516
    AZD0516 will be administered via intravenous infusion.
  • Drug: AZD9574
    AZD9574 will be administered orally.

Recruiting Locations

Research Site
Fayetteville, Arkansas 72703

Research Site
Los Angeles, California 90095

Research Site
Boston, Massachusetts 02114

Research Site
Ann Arbor, Michigan 48109

Research Site
Detroit, Michigan 48201

Research Site
New York, New York 10065

Research Site
Providence, Rhode Island 02906

Research Site
Myrtle Beach, South Carolina 29572

Research Site
Houston, Texas 77030

More Details

Status
Recruiting
Sponsor
AstraZeneca

Study Contact

AstraZeneca Clinical Study Information Center
1-877-240-9479
information.center@astrazeneca.com

Detailed Description

This is a first-in-human modular, Phase I/IIa, open-label, multi-centre study of AZD0516 in participants with metastatic prostate cancer. The study will consist of individual modules, each evaluating the safety, tolerability, preliminary efficacy, PK, pharmacodynamic, and immunogenicity of AZD0516. Module 1: Evaluates AZD0516 as monotherapy. It may include 3 parts, Part A- Dose Escalation, Part B- Dose Optimisation, and Part C- Efficacy Expansion. Module 2: Evaluates AZD0516 in combination with AZD9574. It may include 2 parts, Part A - Dose Escalation and Part B Dose Optimisation.