A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
Purpose
Researchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the bladder. In standard treatment for HR NMIBC, doctors first remove the tumor with a procedure called transurethral resection of the bladder tumor (TURBT). Researchers want to learn if using MK-3120, the study medicine, can treat HR NMIBC after TURBT. The goal of this study is to learn about the safety of MK-3120 and if people tolerate it.
Conditions
- Bladder Cancer
- Urinary Bladder Neoplasms
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Has histologically confirmed carcinoma in situ (CIS) +/- papillary high-risk non-muscle invasive bladder cancer (NMIBC), confirmed locally. - Is an individual whose most recent transurethral resection of bladder tumor (TURBT) was performed within 12 weeks before allocation and showed high-risk NMIBC histology. For individuals with papillary tumors (Ta and T1), a complete TURBT must have been performed, as characterized by attainment of a visually complete resection of all papillary tumors (Ta and T1). - Is either: a) Bacillus Calmette-Guérin (BCG)-naïve, defined as either having never received BCG or having received BCG more than 2 years before CIS +/- papillary high-risk NMIBC recurrence. Recurrence must be at least 24 months from the last exposure to BCG with evidence of complete response during the 2-year period post-BCG OR; b) BCG-exposed and received adequate BCG therapy and had recurrence of CIS +/- papillary high-risk NMIBC >12 months but ≤24 months after the last BCG dose. - Human immunodeficiency virus (HIV)-infected participants must have well-controlled HIV on antiretroviral therapy. - Participants who are hepatitis B surface antigen positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load prior to allocation. - Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening.
Exclusion Criteria
- Has history of or current locally advanced (ie, T2, T3, T4) or metastatic urothelial cancer (UC). - Has concurrent extravesical (ie, urethra, ureter, renal pelvis) non-muscle invasive UC or history of extravesical non-muscle invasive UC that recurred within the last 2 years. - Has active total bladder incontinence, active urinary tract infection, neurogenic bladder, or urethral stricture. - Has a condition that would prohibit normal voiding (or holding bladder voiding for 1 to 2 hours). - Has uncontrolled, significant cardiovascular disease or cerebrovascular disease, including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, uncontrolled symptomatic arrhythmia, prolongation of QTcF interval to >470 ms, and/or other serious cardiovascular and cerebrovascular diseases within the 6 months preceding study intervention. - Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing. - HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease. - Has known additional malignancy that is progressing or has required active treatment within the past 3 years. - Has known active central nervous system metastases and/or carcinomatous meningitis. - Has active infection requiring systemic therapy. - Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids, or has current pneumonitis/ILD. - Has not adequately recovered from major surgery or has ongoing surgical complications.
Study Design
- Phase
- Phase 1/Phase 2
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental MK-3120 |
Participants will be administered MK-3120 once weekly for the first 6 weeks, followed by once monthly for 9 months. |
|
Recruiting Locations
Michael G Oefelein Clinical Trials ( Site 0005)
Bakersfield 5325738, California 5332921 93301
Bakersfield 5325738, California 5332921 93301
Contact:
Study Coordinator
661-310-1063
Study Coordinator
661-310-1063
Carolina Urologic Research Center ( Site 0006)
Myrtle Beach 4588718, South Carolina 4597040 29572
Myrtle Beach 4588718, South Carolina 4597040 29572
Contact:
Study Coordinator
843-449-1010
Study Coordinator
843-449-1010
More Details
- Status
- Recruiting
- Sponsor
- Merck Sharp & Dohme LLC