A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Purpose

The purpose of this study is to look at how safe and well-tolerated LY4167586 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4167586 gets into the bloodstream and how long it takes the body to eliminate it following a single administration. Participation in the study will last approximately 7 months.

Conditions

  • Overweight
  • Obesity

Eligibility

Eligible Ages
Between 18 Years and 65 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Participant must be 21 for Singapore site - Have a body mass index (BMI) between 27.0 kilogram per square meter (kg/m²) and 35.0 kg/m², inclusive - Have had a self-reported stable weight for 3 months prior to screening (less than approximately 5 percent [%] body weight change)

Exclusion Criteria

  • Have a history or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal (GI), endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs, or of constituting a risk when taking the study drug, or of interfering with the interpretation of data. - Is an individual of childbearing potential (IOCBP)

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Basic Science
Masking
Double (Participant, Investigator)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
LY4167586 (Cohorts A1 to A6) 		LY4167586 administered subcutaneously (SC)
  • Drug: LY4167586
    Administered SC
  • Drug: Placebo
    Administered SC
Placebo Comparator
LY4167586 (Cohorts A1 to A6) Placebo 		LY4167586 administered SC
  • Drug: Placebo
    Administered SC
Experimental
LY4167586 (Cohort B) 		LY4167586 administered intravenously (IV)
  • Drug: LY4167586
    Administered IV

Recruiting Locations

Fortrea Clinical Research Unit
Madison, Wisconsin 53704
Contact:
866-429-3700

More Details

Status
Recruiting
Sponsor
Eli Lilly and Company

Study Contact

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
1-317-615-4559
LillyTrials@Lilly.com