Evaluation Of Cardiovascular Health Outcomes Among Survivors 2

Purpose

Childhood cancer survivors who received certain treatments are at a higher risk of developing heart problems in the future. This study is looking at ways to educate childhood cancer survivors about that risk and encourage them to receive a recommended heart screening test.

Condition

  • Health Behavior

Eligibility

Eligible Ages
Over 26 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Childhood Cancer Survivor Study (CCSS) Participants - Age ≥26 years - Treated with cumulative doxorubicin equivalent anthracycline doses ≥100 mg/m2 with any/no radiation, or ≥15 Gy chest radiation with any/no anthracyclines - No history of cardiomyopathy - Has not had an echocardiogram in the previous 5 years - Has a history of successful completion of CCSS surveys - English-Speaking - Has not been enrolled in ECHOS-1 (pilot)

Exclusion Criteria

• Currently participating in a long-term follow-up program that provides risk-based screening

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Other
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Standard of Care (SOC) 		Participants receive a personalized survivorship care plan and educational materials about cardiomyopathy risk and screening recommendations.
  • Behavioral: Survivorship Care Plan + Educational Materials (delivered via CIAS platform)
    Participants receive a personalized survivorship care plan and educational materials about cardiomyopathy risk and screening recommendations. Materials are delivered via the CIAS platform and include infographics, treatment summaries, and general information about screening.
Experimental
Healthy Hearts eHealth Intervention 		Participants receive the same SOC materials plus a tailored eHealth intervention using CIAS. This includes avatar-led motivational interviewing, survivor video vignettes, and interactive modules addressing screening barriers.
  • Behavioral: Healthy Hearts eHealth Program
    Participants receive the same SOC materials plus a tailored, interactive eHealth intervention delivered via the CIAS platform. This includes avatar-led motivational interviewing (MI), survivor video vignettes, interactive modules addressing perceived barriers, self-efficacy, and goal setting. The intervention is designed to mimic MI counseling in a scalable format.

Recruiting Locations

St. Jude Children's Research Hospital
Memphis 4641239, Tennessee 4662168 38105
Contact:
Matthew Ehrhardt, MD, MS, MPI
866-278-5833
referralinfo@stjude.org

More Details

Status
Recruiting
Sponsor
St. Jude Children's Research Hospital

Study Contact

Matthew Ehrhardt, MD, MS, MPI
866-278-5833
referralinfo@stjude.org

Detailed Description

Primary Objective: - To determine the efficacy of the Healthy Hearts eHealth intervention compared to standard of care for improving screening echocardiogram adherence in childhood cancer survivors. Secondary Objective - To determine the efficacy of the Healthy Hearts eHealth intervention compared to standard of care for improving mediators of screening echocardiogram adherence in childhood cancer survivors. After consenting, participants will complete a survey that will take about 15-20 minutes to complete. After this survey, they will be randomly assigned to participate in the Healthy Hearts eHealth Intervention or to receive standard educational materials about hearth health screening. All participants will receive the Standard of Care (SOC) materials delivered via the Computerized Intervention Authoring System (CIAS) platform (i.e., a personalized survivorship care plan and educational materials regarding cardiomyopathy risk and need for screening). In addition to the SOC materials received by controls, the Healthy Hearts eHealth intervention arm will receive CIAS platform delivered Motivational Interview (MI), including scripted interaction with an avatar, video vignettes, and patient testimonials