Conditions

• Non-hodgkin Lymphoma
• Multiple Myeloma

Eligibility

Eligible Ages

Over 18 Years

Eligible Sex

All

Accepts Healthy Volunteers

No

Criteria

Inclusion Criteria:

- Documentation of Disease

o Patients must have pathologically confirmed Diagnosed with non-Hodgkin lymphoma or
multiple myeloma.

- Definition of treatment and ability

- Scheduled to receive an FDA-approved CAR-T product: Axi-cel, Liso-cel,
Tisa-cel, Ide-cel, Cilta-cel, or Brexu-cel.

- Ability to comply with twice daily voice recordings or daily neurologic
assessments, as determined by the investigator.

- Age ≥ 18

- ECOG Performance Status of ≤ 2

- Required

- Perform twice daily voice recordings using a smartphone.

- Undergo daily neurologic assessments (e.g., ICE score, tremor evaluation).

- Smartphone ownership.

- Sufficient English proficiency to complete structured voice tasks in the study
application.

- Comorbid Conditions

- No pre-existing neurological conditions that significantly impair speech,
including but not limited to severe dysarthria, expressive aphasia, or
neurodegenerative disorders.

- No history of significant speech or voice disorders, including laryngeal
paralysis, severe dysphonia, or recent vocal cord surgery or radiation to the
area.

- No pathology affecting the vocal cords that could interfere with voice
analysis, such as vocal cord paralysis, chronic laryngitis, vocal cord nodules,
polyps, granulomas, or malignancies.

- No severe hearing impairment that would interfere with voice assessments

- Language o Proficiency in spoken English is required, without the need for
native-level fluency. This ensures participants can accurately perform structured
voice tasks, as the application and underlying acoustic models are currently
validated only in English, despite the limitation in generalizability. Participants
with language barriers that prevent reliabletask completion or data interpretation
will be excluded.

Recruiting Locations

Study Contact