A Study Of Vagus Nerve Stimulation (VNS) With Mobility Training For Gait Recovery After Chronic Ischemic Stroke
Purpose
The purpose of this study is to evaluate the safety, feasibility, and efficacy of vagus nerve stimulation (VNS) paired with mobility training to improve lower extremity function and gait in individuals with chronic ischemic stroke.
Condition
- Ischemic Stroke
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age ≥ 18 years - Ischemic stroke ≥6 months prior to enrollment. - Post-stroke lower extremity impairment defined as gait velocity of less than 0.8 m/s on a 10-meter walk test - Provision of informed consent
Exclusion Criteria
- Intracerebral Hemorrhage - Active or prior psychosis or substance abuse within two years. - Pre-stroke modified Rankin Scale (mRS) 3-5. - Unable to participate in in-clinic rehabilitation. - Preexisting neurological disorders affecting gait and mobility, such as Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), dementia, major head trauma.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Chronic ischemic stroke |
Participants with chronic ischemic stroke will be treated with a combination of vagus nerve stimulation and mobility training. |
|
Recruiting Locations
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Neurosurgery Research Team
507-293-1283
Neurosurgery Research Team
507-293-1283
More Details
- Status
- Recruiting
- Sponsor
- Mayo Clinic