A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia

Purpose

The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance exercise in people with Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD).

Conditions

  • Fibromuscular Dysplasia
  • Spontaneous Coronary Artery Dissection

Eligibility

Eligible Ages
Between 21 Years and 65 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), ≥2 months post-event, and free from chest pain. - Able to provide written informed consent

Exclusion Criteria

  • Individuals who are clinically obese (BMI ≥36) and/or who suffer from musculoskeletal or other conditions that would limit exercise participation. - Individuals who are deemed medically unstable - Participants who are unable to comply with study requirements. - Pregnancy

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Health Services Research
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Aerobic and resistance exercise 		Patients with a history of Spontaneous Coronary Artery Dissection and/or Fibromuscular Dysplasia will undergo three exercise tests.
  • Behavioral: Aerobic and resistance exercises
    Subjects will undergo three exercise tests, each separated by at least 48 hours: - Symptom-limited cardiopulmonary exercise test (CPET): Patients will cycle upright starting at 0W (3 min) before the workload is increased by 10-35W·min-1 in a ramp fashion (like cycling up a progressively steeper hill) until volitional exhaustion for the determination of V̇O2peak and Wpeak - Two-stage submaximal constant power exercise test: Following a 5-minute warm-up (10-20 W), participants will cycle in the moderate intensity domain for 25 minutes followed by 25 minutes in the heavy intensity domain. - Six different resistance exercises of varying intensities: Participants will perform three sets of six different resistance exercises: chest press; lateral raises; abdominal crunches; planks; leg press; weighted lunges

Recruiting Locations

Mayo Clinic in Florida
Jacksonville, Florida 32224
Contact:
Armia R. Habil, MD
904-953-0859
habil.armia@mayo.edu

More Details

Status
Recruiting
Sponsor
Mayo Clinic

Study Contact

Armia R. Habil, MD
904-953-0859
habil.armia@mayo.edu