A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis
Purpose
This is a phase 2b, multicenter, randomized, double-blind, placebo-controlled study.
Conditions
- Atopic Dermatitis
- Atopic
- Dermatitis
- Dermatitis, Atopic
- Dermatologic Disease
- Eczema
- Eczema Atopic Dermatitis
- Eczema, Atopic
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age 18-65 inclusive, at the time of signing the informed consent. 2. Chronic AD for at least 1 year based on clinically confirmed diagnosis of active AD, according to Hanfin and Rajka criteria. 3. Participants with moderate-to-severe AD defined by: 1. Investigator global assessment (IGA) score of ≥ 3 (on a scale of 0 to 4, in which three is moderate and four is severe) at Screening and Baseline. 2. AD involvement of ≥ 10% body surface area (BSA) at Screening and Baseline. 3. EASI score of ≥ 16 at Screening and at Baseline. 4. Peak pruritus numerical rating scale (PP-NRS) ≥ 4 at Baseline. Note: The PP-NRS will be calculated from the 7 consecutive days immediately preceding Baseline. A minimum of 4 daily scores out of the 7 days is needed. 4. Participants who are candidates for systemic therapy, defined as history of inadequate response to topical AD treatments applied for at least 28 days, or for the maximum duration recommended by the product prescribing information, or for treatment with topical AD treatments is medically inadvisable due to important side effects or safety risks. 5. Contraceptive use should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. 6. Participant provides signed informed consent
Exclusion Criteria
- History or other evidence of severe illness or any other conditions such as psychiatric illness, severe depression or previous history of suicidal attempt in past 10 years that would render the participant, in the opinion of the Investigator, unsuitable for the study. 2. Active, chronic or acute infection requiring systemic antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks before the Baseline. 3. Participant has a current diagnosis of other active skin disease (e.g., psoriasis or lupus erythematosus) or skin infection (bacterial, fungal, or viral) that may affect the evaluation of AD or would interfere with the study assessments based on the Investigator's judgement. 4. Participant has history of significant flares of AD within 4 weeks prior to screening, in the opinion of the investigator. 5. Participant has a severe comorbidity that may require systemic steroids therapy or other interventions or requires active frequent monitoring (e.g., unstable chronic asthma) based on investigator judgement. 6. Any clinically significant abnormalities in rhythm, conduction or morphology of the resting electrocardiogram (ECG) and any clinically significant abnormalities in the 12-lead ECG as considered by the Investigator that may interfere with the interpretation of QTc interval changes. 7. Participant has severe and uncontrolled seasonal or allergic rhinitis, severe and uncontrolled asthma or any other severe and uncontrolled atopic disease as judged by the Investigator. 8. Treatment of AD with medicated moisturizers available only by prescription within 2 weeks prior to the Baseline visit. 9. Active human immunodeficiency virus (HIV): confirmed positive anti-HIV antibody (HIV Ab) test. 10. Active hepatitis B virus (HBV): hepatitis B surface antigen (HBs Ag) positive (+) or hepatitis B core antibody (HBc Ab) positive (+) confirmed by HBV PCR positive (+). 11. Active hepatitis C virus (HCV): If hepatitis C antibody positive (+), confirmed by HCV RNA test. Note: a participant with documented proof of cure from HCV may be enrolled. 12. Evidence of active or latent tuberculosis. 13. Receipt of live or attenuated live vaccine within 6 weeks prior to screening. 14. Participant had a major surgery within 8 weeks prior to Baseline or has a major surgery planned during the study. 15. Participant is known to have immune deficiency or is immunocompromised 16. Diagnosed with a malignancy within 5 years of enrollment (suspected malignancy should be ruled out by blood or tissue biopsy, as applicable) with the exception of: - Completely resected basal cell or squamous cell carcinoma of the skin. - Carcinoma in situ of the cervix. 17. Has had previous exposure to anti-IL-18 therapy. 18. Known allergy/sensitivity to any component of IMP. 19. History of use of any of these medications as follows: 1. Dupilumab, tralokinumab, lebrikizumab, nemolizumab within 8 weeks prior to Baseline. 2. Systemic JAKi within 4 weeks prior to Baseline. 3. Any topical medicated treatment that could affect AD within 2 weeks prior to Baseline, including, but not limited to, topical corticosteroids, topical phosphodiesterase (PDE4) inhibitors, topical calcineurin inhibitors, topical JAKi, tars, antimicrobials, medical devices, and bleach baths. 4. Systemic therapies (other than biologics) that could affect AD not noted above, within 4 weeks prior to Baseline, including but not limited to, retinoids, calcineurin inhibitors, methotrexate, hydroxycarbamide (hydroxyurea), azathioprine, oral/injectable corticosteroids. Note: Intranasal corticosteroids and inhaled corticosteroids are allowed. Eye and ear drops containing corticosteroids are also allowed. 5. Treatment with any investigational biologic agent or biologic agent approved after publication of this protocol, within 12 weeks (or 5 half-lives, whichever is greater) of screening. 6. Treatment with any investigational nonbiologic agent, or any investigational device or procedure, within 4 weeks (or 5 half-lives, whichever is greater) of screening. 7. UV-B phototherapy (including tanning beds) or excimer laser use within 4 weeks prior to Baseline or during the study. 8. PUVA treatment within 4 weeks prior to Baseline 9. Sedating antihistamines, including but not limited to doxepin, hydroxyzine or diphenhydramine within 1 week prior to Baseline 10. Topical products containing urea within 1 week prior to Baseline 11. Systemic antibiotics within 2 weeks or topical antibiotics within 1 week prior to Baseline 12. Intravenous immunoglobulin (IVIg) therapy within 12 weeks prior to Baseline. 20. Female participant who is pregnant or breastfeeding or trying to conceive. 21. Participant considered unlikely to adhere to treatment and/or follow the protocol in the opinion of the Investigator.
Study Design
- Phase
- Phase 2
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Camoteskimab Dose Level 1 |
Camoteskimab administered subcutaneously |
|
|
Experimental Camoteskimab Dose Level 2 |
Camoteskimab administered subcutaneously |
|
|
Experimental Camoteskimab Dose Level 3 |
Camoteskimab administered subcutaneously |
|
|
Placebo Comparator Placebo |
Dummy version of the study drug administered subcutaneously |
|
Recruiting Locations
AllerVie Clinical Research
Birmingham, Alabama 35209
Birmingham, Alabama 35209
Cahaba Dermatology and Skin Health Center
Birmingham, Alabama 35244
Birmingham, Alabama 35244
Saguaro Dermatology Associates
Phoenix, Arizona 85018
Phoenix, Arizona 85018
Dermatology Trial Associates, Inc
Bryant, Arkansas 72022
Bryant, Arkansas 72022
Marvel Research, LLC
Huntington Beach, California 92648
Huntington Beach, California 92648
Metropolis Dermatology
Los Angeles, California 90025
Los Angeles, California 90025
Dermatology Research Associates
Los Angeles, California 90048
Los Angeles, California 90048
Northridge Clinical Trials
Northridge, California 91325
Northridge, California 91325
Integrative Skin Science and Research
Sacramento, California 95815
Sacramento, California 95815
Paradigm Clinical Research Centers, LLC: Wheat Ridge
Wheat Ridge, Colorado 80033
Wheat Ridge, Colorado 80033
ABMED Clinical Research Corp.
Cape Coral, Florida 33904
Cape Coral, Florida 33904
Quality Care Clinical Research
Miami, Florida 33101
Miami, Florida 33101
Ziaderm Research LLC
North Miami Beach, Florida 33162
North Miami Beach, Florida 33162
Ada West Research, LLC
Meridian, Idaho 83646
Meridian, Idaho 83646
DS Research of Southern Indiana,LLC
Clarksville, Indiana 47129
Clarksville, Indiana 47129
Dawes Fretzin Clinical Research Group, LLC
Indianapolis, Indiana 46250
Indianapolis, Indiana 46250
Chesapeake Clinical Research, Inc
Pasadena, Maryland 21122
Pasadena, Maryland 21122
Skin Cancer and Dermatology Institute
Reno, Nevada 89509
Reno, Nevada 89509
Sadick Research Group, LLC
New York, New York 10021
New York, New York 10021
ClinOhio Research Services
Columbus, Ohio 43213
Columbus, Ohio 43213
Best Skin Research, LLC
Camp Hill, Pennsylvania 17011
Camp Hill, Pennsylvania 17011
Progressive Clinical Research, PA
San Antonio, Texas 78213
San Antonio, Texas 78213
More Details
- Status
- Recruiting
- Sponsor
- Apollo Therapeutics Ltd
Study Contact
Detailed Description
This study contains two parts: Part 1 and Part 2. Part 1 (24-Week Placebo-controlled Period): Eligible patients will be randomized in a 1:1:1:1 ratio to receive either camoteskimab dose 1, camoteskimab dose 2, camoteskimab dose 3 or placebo. Part 2 (Extension Period): In part 2, all participants will receive camoteskimab. This study will enroll both treatment-naive participants and those with an inadequate response to previous biologic therapy.