Study of EVO756 in Adults With Migraine

Purpose

This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.

Condition

  • Migraine

Eligibility

Eligible Ages
Between 18 Years and 64 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Adults aged 18 to <65 years - Migraine with or without aura, per ICHD-3 criteria - History of failure with prior preventive migraine treatments - Not currently using migraine preventive therapy

Exclusion Criteria

  • Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders - Use of certain medications - Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Prevention
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Dose 1
Orally administered EVO756, Dose 1 (Daily)
  • Drug: EVO756, Dose 1
    Orally administered EVO756, Dose 1 (Daily)
Experimental
Dose 2
Orally administered EVO756, Dose 2 (Daily)
  • Drug: EVO756, Dose 2
    Orally administered EVO756, Dose 2 (Daily)
Placebo Comparator
Placebo
Placebo control (Daily)
  • Drug: Placebo
    Placebo Control (Daily)

Recruiting Locations

Clinical Neuroscience Solutions, Inc.
Jacksonville, Florida 32256
Contact:
EVO756-MIG001 Research Site
904-281-5757
bsagil@cnshealthcare.com

Clinical Neuroscience Solutions, Inc.
Orlando, Florida 32819
Contact:
(650) 319-4553
nichole.baio@evommune.com

Eximia Research NC
Raleigh, North Carolina 27607
Contact:
EVO756-MIG001 Research Site
(919) 800-5154
achambers@eximiaresearch.com

Clinical Trials of South Carolina
Charleston, South Carolina 29406
Contact:
EVO756-MIG001 Research Site
(650) 319-4553
nichole.baio@evommune.com

FutureSearch Trials of Neurology
Austin, Texas 78731
Contact:
EVO756-MIG001 Research Site
(650) 319-4553
nichole.baio@evommune.com

FutureSearch Trials of Dallas
Dallas, Texas 75251
Contact:
EVO756-MIG001 Research Site
(650) 319-4553
nichole.baio@evommune.com

More Details

Status
Recruiting
Sponsor
Evommune, Inc.

Study Contact

Nichole Baio
(650) 319-4553
nichole.baio@evommune.com