How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants

Purpose

With this study, it is expected to learn more about preterm babies on breathing support with nasal continuous positive airway pressure (nCPAP). To gain more information on how much oxygen is actually delivered to the baby from the nCPAP machine.

Conditions

  • Respiratory Distress Syndrome (Neonatal)
  • Respiratory Distress of Newborn

Eligibility

Eligible Ages
All ages
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical - The infant must be stable while receiving nasal CPAP at any pressure level at the time of study - The infant must be receiving 22-40% at the time of the study

Exclusion Criteria

  • Oxygen requirements greater than 40% at time of enrollment - currently receiving invasive ventilation or not requiring ventilatory support - Major congenital anomalies of the heart and/or lungs

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Supportive Care
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Infants on nCPAP 		All infants on CPAP will have a catheter placed in their oropharynx to measure delivered oxygen and a soft band placed around the infant's chest to measure lung expansion.
  • Device: Effective oxygen delivery and lung expansion measurement
    This intervention arm will involve any infant who is already on nCPAP. It will involve placing a catheter in the infant's oropharynx and wrapping soft EIT bands around the infants chest to measure effective oxygen delivery and lung expansion, respectively.
    Other names:
    • EIT

Recruiting Locations

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Contact:
Sherry Courtney Research Mentor, MD
501-526-1500
SECourtney@uams.edu

More Details

Status
Recruiting
Sponsor
University of Arkansas

Study Contact

Nicholas A Rowley, MD
940-230-5002
NARowley@uams.edu

Detailed Description

This study will tell more about a specific method of breathing support used frequently with preterm babies called nasal continuous positive airway pressure (nCPAP). It helps the baby breathe by providing air pressure and a certain amount of oxygen. It is very important for the baby's health to provide only as much oxygen as they need. With this study, it is expected to learn if the amount of oxygen ordered by a doctor on the nCPAP machine changes when it reaches the baby's airway, and if the amount of oxygen changes depending on how much air pressure the doctor provides. The answers to these questions, are not known, because special measurements are required that are difficult to know while a baby is on nCPAP. This study will collect these special measurements