Low Dose Radiotherapy for Osteoarthritis
Purpose
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Condition
- Osteoarthitis
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- 18 years or older - Diagnosis of OA >3 months in hips, knees, hands, shoulders, ankles or elbows. - Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired. - Provision of signed and dated informed consent.
Exclusion Criteria
- Unable to reasonably complete study instruments.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- N/A
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Other Single |
Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT. |
|
Recruiting Locations
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
More Details
- Status
- Recruiting
- Sponsor
- Abramson Cancer Center at Penn Medicine
Detailed Description
To evaluate the use of select instruments (BPI-SF, LEFS, UEFI, PROMIS Global) to detect changes in pain, function, and well-being in patients with OA who are refractory to or otherwise unable to receive other standard of care therapies.