Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals
Purpose
The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.
Conditions
- Immune System
- Stress
- Chronic Stress
- Cardiovascular Health
Eligibility
- Eligible Ages
- Between 18 Years and 65 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Males and females - 18-65 years old - BMI ≥ 18.5 kg/m2 and ≤ 39.9 kg/ m2 - Recruitment will be based on Perceived Stress Scale - 4 (PSS-4) score
Exclusion Criteria
- Less than 18 and over 65 years old - Pregnant or lactating women - Adults who rely on prescription medication that may influence study variables, apart from birth control - BMI < 18.5 kg/m2 and > 39.9 kg/m2 - Smokers who currently use tobacco- or marijuana-containing products including e-cigarettes, vape pens, pod mods, tanks, and electronic nicotine delivery devices (ENDS) - Habitual consumption of nuts, nut butters, nut powders, nut side dishes, nut bars or other nut products - Known food allergies (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, sesame, corn) due to samples not prepared in a hypoallergenic environment - Currently living in close contact with individuals who have an allergy to peanuts, in order to avoid exposing these individuals to an allergen - Self-reported history of difficulties with blood drawing procedures including prior fainting or dizziness, or veins assessed as not suitable for four separate venipunctures by licensed phlebotomist - Diagnosed active chronic diseases for which the individual is currently taking daily medication, including but not limited to: - Diabetes mellitus, cardiovascular disease, cancer, gastrointestinal disorders, kidney disease, liver disease, bleeding disorders, asthma, autoimmune disorders, hypertension, osteoporosis - Recent minor surgery (within 4 weeks) or major surgery (within 16 weeks) - Known gallbladder disease or history of cholecystectomy - History of gastrointestinal surgery, including gastric bypass surgery or resection - Diagnosis of irritable bowel syndrome - Recent antibiotic therapy (within 4 weeks) - Recent hospitalization (within 4 weeks) - Current participation in another research study - Has HIV/AIDS, hepatitis, or another disease that affects the immune system - Gives regular blood donations and is unwilling to stop during the study - Blood Pressure ≥ 140 mmHg systolic or 90 mmHg diastolic - Current diagnoses of an eating disorder (ex. anorexia, bulimia, etc.) - High - very high triglyceride levels: ≥ 300 mg/dL - Adults who are unable to consent, individuals who are not yet adults (infants, children and teenagers), pregnant women and prisoners will be excluded from participation in the study - Participants who are unwilling to collect and transport urine, stool and saliva samples - Abnormal hemoglobin and/or hematocrit levels - Abnormal liver function (defined as liver enzymes that are >200% of upper limit (ALT upper limit is 43 U/L or Aspartate transaminase (AST) upper limit is 54 U/L) - Unwillingness to discontinue probiotic, prebiotic, fiber, or other supplements (except RDA-level vitamin and mineral supplements) during the study - Unwilling to consume study foods - Alcohol consumption > 20 g/day
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Peanut Intervention followed by corn chips Intervention |
Participants will be asked to consume 42g of peanuts with skin daily for 4 weeks. Following a 4-week washout, the participant will then be asked to consume 45g of corn chips daily for 4 weeks. |
|
|
Experimental Corn chip Intervention followed by Peanut Intervention |
The participant will be asked to consume 45g of corn chips daily for 4 weeks. Following a 4-week washout, the participant will be then asked to consume 42g of peanuts with skin daily for 4 weeks. |
|
Recruiting Locations
Western Human Nutrition Research Center
Davis, California 95616
Davis, California 95616
More Details
- Status
- Recruiting
- Sponsor
- USDA, Western Human Nutrition Research Center
Detailed Description
The overall goal of the proposed study is to determine whether peanut consumption improves indices of cardiovascular disease (CVD) risk in human subjects with high levels of perceived chronic stress. Chronic stress is a growing public health concern and is associated with adverse health outcomes, including CVD. Stress, experienced when a person feels that environmental, physiological, or psychosocial demands tax or exceed their adaptive capacity, triggers a coordinated response from the sympathetic nervous system (SNS) and hypothalamic- pituitary- adrenal (HPA) axis increasing blood pressure, driving systemic inflammation, and affecting the immune system by accelerating the output of disease-promoting immune cells from bone marrow.