Effect of Sage Extract Supplementation on Cognitive Function in Middle-Aged Men and Women
Purpose
Sage (Salvia officinalis) has been reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Several studies indicate that sage supplementation can improve cognitive function. However, more research is needed. The purpose of this study is to examine how sage supplementation affects cognitive function and reaction times in middle-aged men and women.
Condition
- Cognitive Ability, General
Eligibility
- Eligible Ages
- Between 40 Years and 60 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- BMI 18.5-34.9 (inclusive) with a goal of being < 30 on average - Subject agrees to maintain their existing dietary patterns throughout the study period. - Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each test day. - Subject is willing and able to comply with the study protocol. - Has given voluntary, written, informed consent to participate in the study.
Exclusion Criteria
- Individuals with a personal history of a psychiatric disorder. - Individuals who are determined to have liver, renal, cardiovascular, or other metabolic disease. - Current or recent (< 4 weeks) use of any dietary supplements (e.g., choline, lecithin, ginseng, ginkgo biloba, ashwagandha, Bacopa Monnieri, Paullina cupana, Rhodiola rosea, L-theanine, omega-3 fats, Prevagen, etc.), or currently prescribed medications (e.g., Adderall, Mydayis, Ritalin, Concerta, Mythylin, Provigil, Namenda), that may affect cognitive function (focus, concentration, memory, reaction time, energy, etc.). - Alcohol consumption (>2 standard alcoholic drinks/day or >10 drinks/week) or drug abuse/dependence (including regular marijuana or THC use). - Currently a smoker. - Allergy or sensitivity to study product ingredients. - Individuals who are cognitively impaired and/or who are unable to give informed consent. - Any other condition which, in the PI's opinion, may adversely affect the subject's ability to complete the study, its measurements, or pose a significant risk to the subject.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Supportive Care
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Active |
333 mg/day of SageXtra sage extract powder in two #0 capsules (167 mg/capsule). |
|
|
Placebo Comparator Placebo |
333 mg/day of methylcellulose powder in two #0 capsules. |
|
Recruiting Locations
Exercise & Sport Nutrition Lab - Texas A&M University
College Station, Texas 77843
College Station, Texas 77843
More Details
- Status
- Recruiting
- Sponsor
- ESM Technologies, LLC
Detailed Description
To evaluate the effects of sage extract (sageXtra™) on cognitive function and psychomotor performance in middle-aged men and women, subjects (40-60 years) will receive 333 mg of SageXtra or placebo daily for 8 consecutive weeks.