Indirect Calorimetry-Guided Parenteral Nutrition Prescribing in Oncology Patients

Purpose

This study compares two methods of prescribing parenteral nutrition (PN) in adults with cancer who are unable to meet nutritional needs by oral or enteral intake.

Conditions

  • Malnutitrion
  • Cancer

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Adults aged ≥18 years - Diagnosis of cancer - Requirement for PN ≥1 week - Ability to provide informed consent - English-speaking

Exclusion Criteria

  • Hospice enrollment - Mechanical ventilation - Chest tube or drain - Continuous renal replacement therapy - Supplemental oxygen

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Weight-Based Parenteral Nutrition Dosing 		Parenteral nutrition dosed using standard weight-based equations
  • Dietary Supplement: Weight-Based Parenteral Nutrition Dosing
    Parenteral nutrition dosed using standard weight-based equations.
Experimental
Indirect Calorimetry-Guided Parenteral Nutrition Dosing 		Parenteral nutrition dosed based on measured resting energy expenditure
  • Device: Indirect Calorimeter
    Q-NRG + metabolic monitor

Recruiting Locations

Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Contact:
Dylan Sherry, MD
215-728-3544
Dylan.Sherry@fccc.edu

More Details

Status
Recruiting
Sponsor
Fox Chase Cancer Center

Study Contact

Detailed Description

This is a single-center, randomized, open-label pilot study enrolling 50 adult oncology patients requiring PN (parenteral nutrition). Participants are randomized to weight-based dosing or indirect calorimetry-guided dosing. Outcomes include feasibility, acceptability, changes in PN prescription, adverse events, quality of life, and survival.