Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Purpose

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Conditions

  • Osteoarthitis
  • Osteoarthritic Knee Pain
  • Osteoarthritis (OA)
  • Osteoarthritis (OA) of the Knee
  • Osteoarthritis in the Knee

Eligibility

Eligible Ages
Over 40 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Age ≥ 40 - Clinical diagnosis of knee OA with predominant medial compartment symptoms - Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent) - Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee - Able to provide informed consent - Able to complete phone, email, or MyChart follow-ups in English

Exclusion Criteria

  • Predominant lateral compartment OA or patellofemoral-only OA - Inflammatory arthritis (RA, gout flare, etc.) - Suspected or confirmed joint infection or overlying cellulitis - Prior knee arthroplasty on the index knee - Planned surgery for index knee within 12-week follow-up - Inability to complete follow-up assessments - Other clinician-determined contraindication to CSI

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Intervention Model Description
The population will be adults with symptomatic, radiographically moderate-to-severe medial compartment knee osteoarthritis who are already undergoing corticosteroid injections as part of routine care on their native knee. They wil be randomized to receive their injection on either the anteromedial or anterolateral knee.
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Anterolateral 		These patients will receive their corticosteroid injections on their anterolateral knees.
  • Procedure: Anterolateral Injection
    If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.
Active Comparator
Anteromedial 		This group of patients will receive injections on the anteromedial side of their knee.
  • Procedure: Anteromedial Injection
    If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.

Recruiting Locations

Bolingbrook Clinic
Bolingbrook, Illinois 60440
Contact:
Brandon Pardi, M.D.
630-759-1248
brandon.pardi.md@adventhealth.com

Hyde Park Clinic
Chicago, Illinois 60637
Contact:
Sara J Wallace, M.D./M.P.H.
773-834-3531
swallace2@bsd.uchicago.edu

La Grange Clinic
La Grange, Illinois 60525
Contact:
Sara JS Wallace, M.D./M.P.H.
773-834-3531
swallace2@bsd.uchicago.edu

Orland Park Clinic
Orland Park, Illinois 60462
Contact:
Sara JS Wallace, M.D./M.P.H.
888-824-0200
swallace2@bsd.uchicago.edu

Woodridge Clinic
Woodridge, Illinois 60517
Contact:
Brandon Pardi, M.D.
630-759-1248
brandon.pardi.md@adventhealth.com

More Details

Status
Recruiting
Sponsor
University of Chicago

Study Contact

Malik J Scott, B.A.
773-834-3531
mjscott1@uchicago.edu