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Purpose

Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.

Condition

Eligibility

Eligible Ages
Between 18 Years and 60 Years
Eligible Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  1. Fully understanding and willing to undergo study procedures 2. Male or Female greater than or equal to 18 years of age 3. Understanding and willing to sign consent form.

Exclusion Criteria

  1. History of cardiovascular, pulmonary, or neurological disease 2. Hypertension (sitting blood pressure >140/90 mmHg, with measurements recorded on at least 2 occasions) 3. Diabetes 4. Unable to give informed consent; 5. Contra-indication to CMRI testing, including claustrophobia and metallic implants 6. Adherence or retention issues; 7. Women who are pregnant. 8. Allergy to animal dander.

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Diagnostic
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Women w/microvascular disease 		10 women with microvascular disease
  • Other: Handgrip
    Subjects will be asked to squeeze and handgrip dynamometer to increase cardiac metabolic demand
  • Other: Altitude simulation
    Subjects will breathe a lower concentration of oxygen to simulate the effects of altitude.
  • Other: Leg exercise
    Subjects will perform leg exercise to increase metabolic demand.
Experimental
Normal controls 		10 age-matched women with no evidence of microvascular disease
  • Other: Handgrip
    Subjects will be asked to squeeze and handgrip dynamometer to increase cardiac metabolic demand
  • Other: Altitude simulation
    Subjects will breathe a lower concentration of oxygen to simulate the effects of altitude.
  • Other: Leg exercise
    Subjects will perform leg exercise to increase metabolic demand.
Experimental
calibration 		10 healthy individuals who will help to synchronize our imaging and stress testing maneuvers.
  • Other: Handgrip
    Subjects will be asked to squeeze and handgrip dynamometer to increase cardiac metabolic demand
  • Other: Altitude simulation
    Subjects will breathe a lower concentration of oxygen to simulate the effects of altitude.
  • Other: Leg exercise
    Subjects will perform leg exercise to increase metabolic demand.

Recruiting Locations

Cedars-Sinai Medical Center
Los Angeles, California 90048
Contact:
Nicole Tovar
310-248-6960
nicole.tovar@cshs.org

More Details

Status
Recruiting
Sponsor
Cedars-Sinai Medical Center

Study Contact

Barbra Streisand Women's Heart Center
310-423-9666

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.