American Lung Association (ALA) Lung Health Cohort
Purpose
The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.
Condition
- Lung Diseases
Eligibility
- Eligible Ages
- Between 25 Years and 35 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- - Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation. 5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant
Exclusion Criteria
- Severe asthma, which is defined as any of the following: 1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = >250 fluticasone, propionate =100 fluticasone furoate, >200 beclomethasone, >400 budesonide, >220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS. OR 2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR 3. One asthma hospitalization in the past 12 months 2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension 3. Current pregnancy 4. History of cancer other than non-melanoma skin cancer 5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease) 6. Inability to comply with study procedures, including 1. Inability or unwillingness to provide informed consent 2. Inability to perform study measurements 3. Inability to be contacted by phone (via calls and/or text messaging) or email 7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit). 8. Institutionalization
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Recruiting Locations
Birmingham 4049979, Alabama 4829764 35294
Tucson 5318313, Arizona 5551752 85724
Los Angeles 5368361, California 5332921 90095
San Francisco 5391959, California 5332921 94143
Aurora 5412347, Colorado 5417618 80045
Denver 5419384, Colorado 5417618 80206
Jacksonville 4160021, Florida 4155751 32207
Jacksonville 4160021, Florida 4155751 32209
Chicago 4887398, Illinois 4896861 60608
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60612
Iowa City 4862034, Iowa 4862182 52242
Kansas City 4273837, Kansas 4273857 66103
Baltimore 4347778, Maryland 4361885 21218
Ann Arbor 4984247, Michigan 5001836 48109
New York 5128581, New York 5128638 10029
New York 5128581, New York 5128638 10032
Rochester 5134086, New York 5128638 14642
Chapel Hill 4460162, North Carolina 4482348 27517
Durham 4464368, North Carolina 4482348 27710
Winston-Salem 4499612, North Carolina 4482348 27104
Columbus 4509177, Ohio 5165418 43210
Philadelphia 4560349, Pennsylvania 6254927 19140
Pittsburgh 5206379, Pennsylvania 6254927 15213
Charleston 4574324, South Carolina 4597040 29425
Nashville 4644585, Tennessee 4662168 37235
Houston 4699066, Texas 4736286 77030
Colchester 5235024, Vermont 5242283 05446
More Details
- Status
- Recruiting
- Sponsor
- Johns Hopkins University
Detailed Description
The scientific goal of the study is to establish the relationship between a variety of factors (lifetime environmental exposures, fitness and physical activity, biomarkers, nasal respiratory epithelial transcriptome) and ideal versus impaired peak lung health (reserve and markers of susceptibility in investigators' model) in young adulthood. In addition to the initial baseline assessment, remote contacts (e.g., via text message, email, mail, or phone) at regular intervals will allow for both the retention of the participants as well as the collection of additional short-term follow-up information, i.e., within 4.5 years of enrollment. If additional funding becomes available, investigators will extend the study for an additional period of time to study factors related to long-term changes in lung health over time, i.e., at 5 years and beyond. Recruitment of participants will be conducted by the participating study sites along with national and regional efforts from the American Lung Association. Recruitment efforts will be supported by the study web site www.lung.org/lung-study