Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Purpose
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Conditions
- Hypertension
- Obesity
Eligibility
- Eligible Ages
- Between 18 Years and 55 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Control - BMI<30, age 18-55 - Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Exclusion Criteria
All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
Study Design
- Phase
- Early Phase 1
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Basic Science
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Healthy Control |
Healthy age matched controls with no history of cardiovascular disease and normal bodyweight |
|
|
Experimental Hypertensive |
Hypertensive adults who are not obese |
|
|
Experimental Obese |
Obese adults who are not hypertensive |
|
|
Experimental Obese-hypertensive |
Obese adults who are being treated for hypertension |
|
Recruiting Locations
University of Texas Southwestern Medical Center
Dallas, Texas 75231
Dallas, Texas 75231
More Details
- Status
- Recruiting
- Sponsor
- University of Texas Southwestern Medical Center