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Purpose

This is a randomized, double-blind, placebo controlled, dose-ranging Phase 2 study. The primary objective is to evaluate the efficacy and safety of SAR443122 compared to placebo in participants with moderate to severe UC. Dose selection for further clinical development will be based on the multiple efficacy, safety and PK parameters. The study consists of 4 parallel arms (3 dose groups of SAR443122 vs placebo) to assess the efficacy and safety of SAR443122 in participants with moderate to severe UC. All participants will receive a total of 52 weeks (a 12-week induction treatment phase and a 40-week maintenance phase) of study treatment, except if treatment should be discontinued per investigator's assessment. At the end of the first 12 weeks of induction treatment, all participants in clinical response or remission will be offered study treatment up to 40 weeks and will continue with the same blinded treatment that was assigned. Participants who do not achieve clinical response or remission at the end of the initial 12 weeks induction treatment will roll over in an open-label treatment arm and will be treated with SAR443122 at the highest tested dose. In addition, participants from the maintenance treatment that lose clinical efficacy at any time up to V10/Week 40 (Week 28 of maintenance) will be offered to roll over in the open-label treatment arm with SAR443122 at the highest dose.

Condition

Eligibility

Eligible Ages
Between 18 Years and 75 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Participants who have clinical evidence of active Ulcerative Colitis [UC] for ≥3 months before screening as confirmed by endoscopy during the screening period. - Participants must have a minimum disease extent of 15 centimeters from the anal verge. - Participants are inadequate or non-responders, have shown loss of response, or are intolerant to at least 1 of following approved treatments: amino-salicylate, corticosteroids, immunosuppressants or biologics other than natalizumab (Tysabri®) or small molecules. - Participants on corticosteroids must be on a stable dose ≥2 weeks prior to screening and during screening period. - Participants on methotrexate, azathioprine or 6- mercaptopurine must be on treatment for at least 8 weeks prior to screening; and on a stable dose ≥4 weeks prior to screening and during screening period. - Participants on oral 5-aminosalicylates, mesalamine or sulfasalazine must be on a stable dose for ≥4 weeks prior to screening and during screening period. - Participants on advanced therapies must have 1) last administration at least 5 half-lives prior to randomization, or 2) undetectable level of the biologic in their blood prior to randomization. - Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. Women participants should not be pregnant or breastfeeding.

Exclusion Criteria

  • Participants with Crohn's Disease (CD). - Participants with diagnosis of indeterminate colitis or microscopic colitis. - Participants with stool sample positive for culture for aerobic pathogens or C difficile. - Participants with prior colectomy or anticipated colectomy during their participation in the study. - Participants with presence of ileal pouch or ostomy. - Participants with fulminant disease or toxic megacolon. - Participants with colonic dysplasia except for adenoma. - Participants with intestinal failure or short bowel syndrome requiring Total Parenteral Nutrition (TPN). - Participants with history of recurrent or recent serious infection that has not resolved within 4 weeks prior to randomization. - Participants presenting with active malignancies or recurrence of malignancy within the 5 years before screening. - Participants with a history or presence of another significant illness that according to the investigator's judgment would adversely affect the subject's ability to participate in this study. - Participants presenting with fever (≥38°C) or persistent chronic or active recurring infection within 4 weeks prior to the Screening Visit requiring treatment with antibiotics, antivirals, or any history of frequent recurrent infections deemed unacceptable per investigator's judgment. - Participants who were administered any live (attenuated) vaccine within 3 months prior to the randomization Visit. - Participants with a history of recurrent herpes zoster. - Participants with uncontrolled diabetes, defined as HbA1c ≥9.0% at the Screening Visit. - Participants with active tuberculosis (TB) or non-tuberculous mycobacterial infection, or a history of incompletely treated active or latent TB per local guidelines will be excluded from the study unless it is documented by a specialist that the participant has been adequately treated and can now start treatment with the RIPK1 kinase inhibitor. - Participants presenting with opportunistic infections within six months prior to screening or while receiving anti-TNF treatment in the last 6 months. - Participants undergoing hemodialysis or peritoneal dialysis. - Participants with a known history of Human Immunodeficiency Virus (HIV) infection or positive HIV serology at screening. - Participants with Positive Hepatitis B surface antigen (HBsAg) or positive Hepatitis B core antibody (HBcAb); and/or positive Hepatitis C antibody (HCV) at the Screening Visit. Participants that were treated for HCV and clear the virus documented by HCV RNA by PCR below the limit of quantification can be eligible. - Positive COVID-19 test, suspected COVID-19 infection or known exposure to COVID-19 during the screening period. - History of COVID-19 infection within 4 weeks prior to Screening; history of mechanical ventilation or extracorporeal membrane oxygenation (ECMO) due to COVID-19 infection within 3 months prior to Screening or with residual significant complications from COVID-19 making it unsafe for the participant to enter this study. - Participants presenting alcohol or drug dependency within the 2 years prior to the Screening Visit. - Participants with unexplained, uncontrolled, or untreated thyroid disease or unexplained abnormal serum prolactin levels at screening. - Participants under cyclosporine, mycophenolate mofetil, sirolimus (rapamycin), thalidomide or tacrolimus treatment within 4 weeks prior to screening. - Participants with previous exposure to natalizumab (Tysabri®). - Participants with previous exposure to RIPK1 inhibitor. - Participants under antidiarrheals within 2 weeks prior to screening and during screening period. - Participants under prednisone >25 mg/day (or equivalent). - Participants under budesonide >9 mg/day. - Participants who received intravenous corticosteroids or cytapheresis therapy within 2 weeks prior to screening or during screening. - Participants who were rectally administered topical 5-aminosalicylate or corticosteroids within 4 weeks prior to screening. - Participants who received therapeutic enema or suppository, other than required for colonoscopy or flexible sigmoidoscopy within 4 weeks prior to screening or during screening. - Participants who received antibiotics for UC or gastrointestinal infection within 4 weeks prior to screening. - Participants who have taken other investigational medications within 2 months or 5 half--lives, (whichever is longer) prior to screening. - Presence of significant laboratory findings at the Screening Visit. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
SAR443122 level 1 		Dose level 1
  • Drug: SAR443122
    oral capsule
Experimental
SAR443122 level 2 		Dose level 2
  • Drug: SAR443122
    oral capsule
Experimental
SAR443122 level 3 		Dose level 3
  • Drug: SAR443122
    oral capsule
Placebo Comparator
Placebo 		Matching Placebo
  • Drug: Placebo
    oral capsule

Recruiting Locations

Om Research - Lancaster - 15th Street West- Site Number : 8400014
Lancaster 5364940, California 5332921 93534

Agile Clinical Research Trials- Site Number : 8400024
Atlanta 4180439, Georgia 4197000 30328

Endeavor Health - Evanston Hospital- Site Number : 8400027
Evanston 4891382, Illinois 4896861 60201

BVL Research- Site Number : 8400015
Liberty 4395052, Missouri 4398678 64068

Vector Clinical Trials- Site Number : 8400004
Las Vegas 5506956, Nevada 5509151 89128

Sanmora Bespoke Clinical Research Solutions- Site Number : 8400016
East Orange 5097441, New Jersey 5101760 07018

NY Scientific- Site Number : 8400013
Brooklyn 5110302, New York 5128638 11235

Pioneer Clinical Research - New York- Site Number : 8400017
New York 5128581, New York 5128638 10016

Houston Methodist Hospital- Site Number : 8400023
Houston 4699066, Texas 4736286 77030

1960 Family Practice- Site Number : 8400019
Houston 4699066, Texas 4736286 77090

GI Alliance - Mansfield- Site Number : 8400010
Mansfield 4709013, Texas 4736286 76063

Integrity Research - Sugar Land- Site Number : 8400026
Sugar Land 4734825, Texas 4736286 77478

Richmond VA Medical Center- Site Number : 8400022
Richmond 4781708, Virginia 6254928 23249

More Details

Status
Recruiting
Sponsor
Sanofi

Study Contact

Trial Transparency email recommended (Toll free number for US & Canada)
800-633-1610
contact-us@sanofi.com

Detailed Description

Total study duration per participant will be up to 58 weeks, including a screening period of up to 4 weeks, a treatment period up to 52 weeks and a post-treatment follow-up period of 2 weeks.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.