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Purpose

Study CJB-101-01 will be conducted at multiple centers in the USA and Republic of Korea as an open-label safety and preliminary efficacy study of CJRB-101 in combination with pembrolizumab in subjects with selected types of advanced or metastatic cancer. The proposed study intends to address the unmet medical needs of low response rate and refractoriness to immune checkpoint inhibitors typically observed in this subject population by performing assessments of response, dose limiting toxicities, pharmacodynamic, and the effect on microbiome biomarkers at different dose levels of CJRB-101 combined with pembrolizumab.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  1. Willing and able to provide informed consent 2. ≥18 years of age at the time of signing the informed consent form 3. Pathologically documented histological or cytological evidence of NSCLC, HNSCC, or melanoma. 4. Has at least 1 measurable target lesion per RECIST v1.1 that has not been resected/biopsied/or irradiated before enrollment in the study 5. Diagnosis of locally advanced unresectable or metastatic NSCLC, HNSCC, or melanoma in subjects who are ICI treatment-naive or relapsed/refractory, including PD-1/PD-L1 inhibitors 6. ICI treatment-naive subjects must meet the following criteria: 1. NSCLC: Subjects with metastatic or with unresectable, recurrent NSCLC whose tumors must have no EGFR or ALK genomic aberrations and express PD-L1 [TPS≥50%] 2. HNSCC: Subjects with metastatic or with unresectable, recurrent HNSCC whose tumors express PD-L1 [CPS ≥20] 3. Melanoma: Irrespective of PD-L1 result and BRAF V600 mutation 4. Subjects has not received prior systemic treatment for their metastatic tumor. Subjects who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 6 months before the development of metastatic disease. 7. ICI treatment-refractory subjects as defined by the following criteria: 1. Has received at least 2 cycles of anti-PD-(L)1 therapy either as monotherapy or in combination 2. Has demonstrated disease progression after ICI treatment by RECIST v1.1 3. Has received less than three lines of systemic therapy for metastatic tumor 8. ECOG performance status of 0 or 1 9. Be willing to provide archival tissue or fresh biopsy 10. Have adequate organ function 11. All Grade 3 or greater AEs resolved earlier to Grade 2 or less

Exclusion Criteria

  1. Cancer type and genomic tumor aberrations: 1. NSCLC subjects with EGFR or ALK genomic tumor aberrations 2. HNSCC subjects with nasopharyngeal cancer 2. For ICI refractory/relapsed subjects: Immune related AEs ≥Grade 3 that led to discontinuation of prior immune-modulatory agents including PD-1/PD-L1 inhibitors 3. With uncontrolled or untreated brain metastasis or leptomeningeal disease 4. Active autoimmune disease that has required systemic treatment in the past 2 years 5. Received a fecal transplant 6. Concurrent participation in another interventional clinical study or use of another investigational agent within 30 days of study consent 7. Contraindication to IV contrast that cannot be managed with pre-medication 8. Female subjects who are pregnant or breastfeeding 9. Male subjects who are unwilling or unable to use an acceptable method of birth control to avoid pregnancy 10. Has a known inability for oral intake of capsules 11. Has received a live vaccine within 4 weeks of start of the study treatment 12. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy 13. Has received whole blood transfusion, blood component transfusion, or colony stimulating factors within 1 week prior to the 1st dose of study treatment 14. In the judgment of the investigator, subjects unlikely to comply with study procedures, restrictions and requirements 15. Has active interstitial lung disease (ILD)/pneumonitis or a history of ILD/pneumonitis requiring treatment with systemic steroids 16. Have allergy to clindamycin, erythromycin, and ampicillin 17. Has signs and symptoms of colitis at screening 18. Infection requiring systemic antibacterial, antifungal, or antiviral therapy within 14 days before study treatment (Note: Antiviral therapy is permitted for subjects with chronic HBV or HCV infection) 19. Untreated chronic hepatitis B or chronic HBV carriers with HBV DNA>500 IU/mL (or >2500 copies/mL) at screening (Note: Inactive hepatitis B surface antigen (HbsAg) carriers, treated and stable hepatitis B (HBV DNA < 500 IU/mL or < 2500 copies/mL) can be enrolled. Subjects with detectable HbsAg or detectable HBV DNA should be managed per treatment guidelines. Subjects receiving antivirals at screening should have been treated for > 2 weeks before study treatment.) 20. With active hepatitis C (Note: Subjects with a negative HCV antibody test at screening or positive HCV antibody test followed by a negative HCV ribonucleic acid (RNA) test at screening are eligible. The HCV RNA test will be performed only for subjects testing positive for HCV antibody. Subjects receiving antivirals at screening should have been treated for > 2 weeks before study treatment.) 21. Known history of HIV infection 22. History of active inflammatory bowel disease with diarrhea believed to be caused by active inflammatory bowel disease in the past 12 months 23. Major surgery for any reason, except diagnostic biopsy, within 4 weeks of study informed consent and or if the subject has not fully recovered from the surgery within 4 weeks of informed consent 24. History of major gastrointestinal surgery 25. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial 26. Currently active, clinically significant cardiovascular disease 27. Known active intravenous drug or alcohol abuse or use of other drugs of abuse 28. Has any contraindication as mentioned in the recent Keytruda, Highlights of Prescribing Information (pembrolizumab)

Study Design

Phase
Phase 1/Phase 2
Study Type
Interventional
Allocation
N/A
Intervention Model
Sequential Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
CJRB-101 with pembrolizumab 		Phase 1 includes patients with selected types of advanced or metastatic cancers. Patients will be given with either low or high dose levels of CJRB-101 in combination with pembrolizumab. Phase 2 includes patients with selected types of advanced or metastatic cancers. Patients will be given with the CJRB-101 dose selected from Phase 1 in combination with pembrolizumab.
  • Drug: CJRB-101
    In Phase 1, one or two capsules of CJRB-101 will be given every day. In Phase 2, the CJRB-101 dose selected from Phase 1 will be given every day.
  • Drug: Pembrolizumab injection
    200 mg given by intravenous (IV) infusion once every 3 weeks

Recruiting Locations

University of California, Irvine
Irvine, California 92697
Contact:
Misako Nagasaka, MD, PhD

University of Pittsburgh
Pittsburgh, Pennsylvania 15260
Contact:
Diwakar Davar, MD

More Details

Status
Recruiting
Sponsor
CJ Bioscience, Inc.

Study Contact

Hyun Kim
+82-2-6078-3456
clinical.development@cj.net

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.