Print

Purpose

The effects of diet on inflammatory bowel disease is an under-studied area of research. The investigators are interested in further investigating the role that diet contributes to inflammatory bowel disease severity. The investigators will collect blood and stool samples from patients with inflammatory bowel disease (IBD) before and after diet changes. The stool samples will be analyzed using metabolomics and microbiome analysis to determine changes after the new diet has been implemented. The investigators will then compare changes in the patient's overall disease state by measuring markers of inflammation including C-reactive protein (CRP) and fecal calprotectin to determine how this diet affects the disease state.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • 18 years old or older - Meet classification criteria for inflammatory bowel disease including those with mild to moderate Crohn's Disease as defined by a Crohn's disease activity index between 150-450, with fecal calprotectin>250, within 1 month of enrollment.

Exclusion Criteria

  • Unable to provide informed consent - History of or current drug abuse - Pregnancy - Start or change in dose of standard-of-care treatment within 12 weeks of the screening - Known allergy to any component of the proposed diet - Subjects with significant other medical or psychiatric comorbidities and /or medication use which in - physician's clinical judgment might difficult the interpretation of the results - Patients that are not on a stable dose of medications, for instance, steroids, in between samples collection - Patients on antibiotics - Patients with C difficile infection within 4 weeks of enrollment

Study Design

Phase
N/A
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Mediterranean Diet 		Mediterranean Diet for 42 Days
  • Dietary Supplement: Mediterranean Diet
    Mediterranean Diet for 42 Days

Recruiting Locations

University of California, San Diego
San Diego, California 92161
Contact:
Monica Guma, M.D, PHD
mguma@health.ucsd.edu

More Details

Status
Recruiting
Sponsor
University of California, San Diego

Study Contact

Monica Guma, M.D., PhD
8588226523
mguma@health.ucsd.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.