Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
Purpose
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.
Conditions
- Type 2 Diabetes
- Insulin Resistance
- Obesity
- Metabolic Disease
- PreDiabetes
Eligibility
- Eligible Ages
- Between 14 Years and 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Between 14 and 18 years of age - Tanner stage 4 or 5 (mature adult stage of puberty) - Normal weight (BMI ≥ 5th percentile & < 85th percentile), overweight (BMI > 86th percentile) & < 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c > 5.7%) - For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes
Exclusion Criteria
- Currently pregnant - Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management - Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff - Allergies or intolerance to milk, soy, or palm oil
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross-Sectional
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Normal weight | BMI ≥ 5th percentile & < 85th percentile | |
| Obese weight | BMI ≥ 95th percentile | |
| PreDiabetes | HbA1c > 5.7% | |
| Type 2 Diabetes | Diagnosed with Type 2 Diabetes | |
| Overweight | BMI > 86th percentile and <94th percentile |
Recruiting Locations
University of Michigan
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
More Details
- Status
- Recruiting
- Sponsor
- University of Michigan