Identification of Metabolic Phenotypes Associated With Melanoma Metastasis
Purpose
The goal of this study is to observe metabolic features associated with human melanoma tumors.
Condition
- Melanoma (Skin)
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients with known or probable malignant melanoma lesions requiring surgical biopsy or excision. - Subjects of all races and ethnic origins over age 18.
Exclusion Criteria
- Not a surgical candidate - Poorly controlled diabetes
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Case-Only
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| 13C-glucose infusion | Tumor samples of patients who receive the optional 13C-glucose infusion will be studied using flux analysis and metabolomic profiling. | |
| No 13C-glucose infusion | Tumor samples of patients who do not receive the optional 13C-glucose infusion will be studied using metabolomic profiling alone. |
Recruiting Locations
University of Texas Southwestern Medical Center
Dallas, Texas 75390
Dallas, Texas 75390
More Details
- Status
- Recruiting
- Sponsor
- University of Texas Southwestern Medical Center
Detailed Description
This is a single center, correlative study designed to assess metabolic features of melanoma tumors in patients. The study will involve the collection of melanoma tissue at the time of surgical biopsy or excision. All samples will be assessed by mass spectrometry for metabolomic analysis. A subset of patients will have received [U-13C]glucose infusions which will be utilized for isotope tracing metabolic analysis. Relevant clinical data (eg survival, metastasis) will be correlated with metabolic findings.