Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Purpose
This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed therapies with chemotherapy and/or (immune checkpoint inhibitors) ICIs.
Conditions
- Breast Carcinoma
- Colorectal Carcinoma
- Lung Non-Small Cell Carcinoma
- Melanoma
- Non-Hodgkin Lymphoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Adults aged 18 years or older with one of the following newly diagnosed cancers: breast cancer, colorectal cancer, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer (e.g. adenocarcinoma, squamous cell carcinoma, large cell carcinoma, adenosquamous cell carcinoma, and not otherwise specified). - Planned treatment with systemic chemotherapy (single or multi-agent, includes targeted therapy) and/or immune checkpoint inhibitor therapy (targeting PD-1, PD-L1 or CTLA-4). If unable to engage participant before treatment starts, enrollment is allowed up to the start of Cycle 2 treatment. - Participants must be able to comprehend English or Spanish (for survey completion). - Participants must have a working email address and be must be willing to complete surveys online. This can be completed at home, in the clinic or other location. - Completion of the confidential Self-Reported Screening Survey and receipt of a screening result - eligible for enrollment. - Participant must reside in the United States, officially determined per patient report on Self-reported Screening Survey - In the treating provider's opinion, the participant should have a life expectancy of >=6 months. Participants in hospice are not eligible. Optional Sub-study (available at select sites only): - Must be willing to participate in both the main study and the sub-study at the Wake Forest University Comprehensive Cancer Center (WF CCC) and Virginia Commonwealth University (VCU). - Must be receiving treatment at the WF CCC and VCU. - Must be diagnosed with non-small cell lung cancer. - Must be planning to receive paclitaxel as part of their chemotherapy in conjunction with Immune Checkpoint Inhibitor (ICIs) PD-1, PD-L1 or CTLA-4.
Exclusion Criteria
- Currently enrolled in an interventional supportive treatment trial to manage cancer symptoms. - Participants with known pregnancy. - Participant received systemic therapy treatment for prior cancer(s) including chemotherapy, immunotherapy, targeted therapy, and hormonal therapy. - Participants enrolled in hospice. Optional Substudy (available at select sites only): - Participants with chronic or ongoing steroid or immunomodulatory agents (i.e., prednisone, dexamethasone, etanercept, infliximab, etc.). The use of glucocorticoids as pre-medications for chemotherapy treatment is allowed. - Participants with a history of HIV, hepatitis B or hepatitis C.
Study Design
- Phase
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
| Observational | Participants complete surveys and have their medical records reviewed on study. |
|
Recruiting Locations
Fairbanks, Alaska 99701
Phoenix, Arizona 85004
Fort Smith, Arkansas 72903
800-378-9373
Jonesboro, Arkansas 72401
870-936-7066
Antioch, California 94531
Arroyo Grande, California 93420
Carmichael, California 95608
Carmichael, California 95608
Dublin, California 94568
877-642-4691
Elk Grove, California 95758
Fresno, California 93720
833-574-2273
Martinez, California 94553-3156
925-957-5400
Martinez, California 94553
925-957-5400
Modesto, California 95356
877-642-4691
Redwood City, California 94063
877-642-4691
Rocklin, California 95765
Sacramento, California 95816
San Jose, California 95119
San Luis Obispo, California 93401
Santa Clara, California 95051
Santa Maria, California 93444
Santa Rosa, California 95403
707-521-3830
South San Francisco, California 94080
St. Helena, California 94574
707-967-3698
Stockton, California 95204
209-461-5257
Vacaville, California 95688
Woodland, California 95695
Aurora, Colorado 80012
Boulder, Colorado 80304
Centennial, Colorado 80112
303-777-2663
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80923
Denver, Colorado 80218
Denver, Colorado 80218
Denver, Colorado 80220
Lafayette, Colorado 80205
Littleton, Colorado 80120
Lone Tree, Colorado 80124
Thornton, Colorado 80260
Westminster, Colorado 80023
Millville, Delaware 19967
Newark, Delaware 19713
Newark, Delaware 19713
Rehoboth Beach, Delaware 19971
Clearwater, Florida 33756
855-314-8646
Plant City, Florida 33563
St. Petersburg, Florida 33705
Tampa, Florida 33607
Duluth, Georgia 30096
Hinesville, Georgia 31313
Lawrenceville, Georgia 30046
Macon, Georgia 31201
Savannah, Georgia 31405
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
808-532-0315
Honolulu, Hawaii 96813
808-545-8548
Honolulu, Hawaii 96813
808-522-4333
Honolulu, Hawaii 96817
808-531-8521
Honolulu, Hawaii 96819
Honolulu, Hawaii 96826
808-983-6090
Honolulu, Hawaii 96859
808-433-6336
Lihue, Hawaii 96766
808-535-7960
‘Aiea, Hawaii 96701
‘Aiea, Hawaii 96701
808-486-6000
‘Aiea, Hawaii 96701
808-522-4333
Boise, Idaho 83706
Caldwell, Idaho 83605
Coeur d'Alene, Idaho 83814
Nampa, Idaho 83687
Post Falls, Idaho 83854
Sandpoint, Idaho 83864
Alton, Illinois 62002
618-463-5623
Aurora, Illinois 60504
Barrington, Illinois 60010
847-842-4847
Bloomington, Illinois 61704
Canton, Illinois 61520
Carthage, Illinois 62321
Centralia, Illinois 62801
Chicago, Illinois 60612
312-864-5204
Chicago, Illinois 60657
773-296-5360
Crystal Lake, Illinois 60014
Decatur, Illinois 62526
Dixon, Illinois 61021
815-285-7800
Downers Grove, Illinois 60515
Effingham, Illinois 62401
Elgin, Illinois 60123
847-429-2907
Eureka, Illinois 61530
Galesburg, Illinois 61401
Hazel Crest, Illinois 60429
708-799-9995
Kewanee, Illinois 61443
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Macomb, Illinois 61455
Mattoon, Illinois 61938
Mount Vernon, Illinois 62864
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Oak Lawn, Illinois 60453-2699
800-323-8622
Ottawa, Illinois 61350
Park Ridge, Illinois 60068
847-384-3621
Pekin, Illinois 61554
Peoria, Illinois 61615
Peru, Illinois 61354
Princeton, Illinois 61356
Rockford, Illinois 61108
815-227-2633
Springfield, Illinois 62702
217-545-7929
Springfield, Illinois 62702
800-444-7541
Springfield, Illinois 62781
Washington, Illinois 61571
Yorkville, Illinois 60560
Michigan City, Indiana 46360
Ankeny, Iowa 50023
515-241-3305
Bettendorf, Iowa 52722
Cedar Rapids, Iowa 52402
319-297-2900
Cedar Rapids, Iowa 52403
319-363-2690
Clive, Iowa 50325
Clive, Iowa 50325
515-241-3305
Des Moines, Iowa 50309
515-241-6727
Des Moines, Iowa 50309
515-241-3305
Des Moines, Iowa 50314
515-282-2200
Des Moines, Iowa 50314
Des Moines, Iowa 50314
515-241-3305
Iowa City, Iowa 52242
800-237-1225
Waukee, Iowa 50263
515-241-3305
Hays, Kansas 67601
785-623-5774
Olathe, Kansas 66061
Overland Park, Kansas 66210
Overland Park, Kansas 66211
Topeka, Kansas 66606
785-270-4939
Topeka, Kansas 66606
785-295-8000
Westwood, Kansas 66205
Bardstown, Kentucky 40004
Lexington, Kentucky 40509
London, Kentucky 40741
Mount Sterling, Kentucky 40353
Paducah, Kentucky 42003
Monroe, Louisiana 71202
Shreveport, Louisiana 71103
Augusta, Maine 04330
207-626-4855
Belfast, Maine 04915
Biddeford, Maine 04005
Brunswick, Maine 04011
Rockport, Maine 04856
Sanford, Maine 04073
Sanford, Maine 04073
207-459-1600
Scarborough, Maine 04074
South Portland, Maine 04106
Baltimore, Maryland 21201
800-888-8823
Baltimore, Maryland 21215
Elkton, Maryland 21921
Glen Burnie, Maryland 21061
410-553-8100
Towson, Maryland 21204
Westminster, Maryland 21157
410-871-6400
Alma, Michigan 48801
Alpena, Michigan 49707
Ann Arbor, Michigan 48106
Escanaba, Michigan 49829
Gladwin, Michigan 48624
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Iron Mountain, Michigan 49801
Kalamazoo, Michigan 49007
Midland, Michigan 48670
Mount Pleasant, Michigan 48858
Muskegon, Michigan 49444
Norton Shores, Michigan 49444
616-391-1230
Pontiac, Michigan 48341
Reed City, Michigan 49677
Saginaw, Michigan 48601
Tawas City, Michigan 48764
Traverse City, Michigan 49684
Wyoming, Michigan 49519
Albert Lea, Minnesota 56007
855-776-0015
Brainerd, Minnesota 56401
Burnsville, Minnesota 55337
Deer River, Minnesota 56636
Detroit Lakes, Minnesota 56501
Duluth, Minnesota 55805
Fosston, Minnesota 56542
Hibbing, Minnesota 55746
218-786-3308
Mankato, Minnesota 56001
855-776-0015
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Minneapolis, Minnesota 55407
Minneapolis, Minnesota 55415
Monticello, Minnesota 55362
Park Rapids, Minnesota 56470
Princeton, Minnesota 55371
Robbinsdale, Minnesota 55422
Rochester, Minnesota 55905
855-776-0015
Saint Cloud, Minnesota 56303
Saint Louis Park, Minnesota 55416
Sandstone, Minnesota 55072
Shakopee, Minnesota 55379
Springfield, Minnesota 65807
417-269-4520
Virginia, Minnesota 55792
Woodbury, Minnesota 55125
Columbus, Mississippi 39705
Grenada, Mississippi 38901
New Albany, Mississippi 38652
Oxford, Mississippi 38655
Southaven, Mississippi 38671
Ballwin, Missouri 63011
888-446-3729
Ballwin, Missouri 63011
314-251-7058
Farmington, Missouri 63640
314-996-5569
Kansas City, Missouri 64108
816-404-4375
Kansas City, Missouri 64116
913-588-3671
Kansas City, Missouri 64154
Lee's Summit, Missouri 64064
Osage Beach, Missouri 65065
Saint Joseph, Missouri 64506
Sainte Genevieve, Missouri 63670
314-996-5569
Sainte Genevieve, Missouri 63670
314-996-5569
Springfield, Missouri 65804
417-269-4520
Springfield, Missouri 65807
417-269-4520
St Louis, Missouri 63131
314-996-5569
St Louis, Missouri 63141
314-251-7066
Sullivan, Missouri 63080
314-996-5569
Sunset Hills, Missouri 63127
314-996-5569
Billings, Montana 59101
Great Falls, Montana 59405
Kearney, Nebraska 68847
Henderson, Nevada 89052
Las Vegas, Nevada 89102
Englewood, New Jersey 07631
201-894-3456
Freehold, New Jersey 07728
732-303-5047
Hackettstown, New Jersey 07840
973-971-5990
Morristown, New Jersey 07960
973-971-5900
Newton, New Jersey 07860
973-971-5990
Pompton, New Jersey 07444
973-971-5990
Summit, New Jersey 07901
908-522-2043
Teaneck, New Jersey 07666
201-833-6312
Albuquerque, New Mexico 87102
Albuquerque, New Mexico 87102
Las Cruces, New Mexico 88011
Rio Rancho, New Mexico 87124
702-384-0013
Glens Falls, New York 12801
The Bronx, New York 10461
The Bronx, New York 10467
Albemarle, North Carolina 28002
800-804-9376
Asheboro, North Carolina 27205
Burlington, North Carolina 27215
Charlotte, North Carolina 28203
800-804-9376
Charlotte, North Carolina 28210
980-442-2000
Charlotte, North Carolina 28211
980-442-2000
Charlotte, North Carolina 28262
800-804-9376
Charlotte, North Carolina 28277
800-804-9376
Clemmons, North Carolina 27012
888-716-9259
Concord, North Carolina 28025
800-804-9376
Forest City, North Carolina 28043
800-804-9376
Gastonia, North Carolina 28054
Gastonia, North Carolina 28054
800-804-9376
Greensboro, North Carolina 27403
Greensboro, North Carolina 27410
High Point, North Carolina 27262
336-802-2500
Huntersville, North Carolina 28078
980-442-2000
Lincolnton, North Carolina 28092
704-671-7031
Matthews, North Carolina 28104
980-442-0600
Monroe, North Carolina 28112
980-442-2000
Reidsville, North Carolina 27320
Shelby, North Carolina 28150
800-804-9376
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-713-6771
Fargo, North Dakota 58103
Beavercreek, Ohio 45431
Dayton, Ohio 45415
Findlay, Ohio 45840
Franklin, Ohio 45005
Kettering, Ohio 45409
Kettering, Ohio 45429
Youngstown, Ohio 44501
Oklahoma City, Oklahoma 73120
405-752-3402
Baker City, Oregon 97814
Ontario, Oregon 97914
Allentown, Pennsylvania 18103
Bethlehem, Pennsylvania 18017
Chambersburg, Pennsylvania 17042
717-217-6020
Danville, Pennsylvania 17822
Dickson City, Pennsylvania 18519
East Stroudsburg, Pennsylvania 18301
Ephrata, Pennsylvania 17522
717-721-4840
Gettysburg, Pennsylvania 17325
877-441-7957
Hazleton, Pennsylvania 18201
Hazleton, Pennsylvania 18201
Lebanon, Pennsylvania 17042
Lewisburg, Pennsylvania 17837
Pottsville, Pennsylvania 17901
Scranton, Pennsylvania 18510
Wilkes-Barre, Pennsylvania 18711
York, Pennsylvania 17403
877-441-7957
Anderson, South Carolina 29621
Bluffton, South Carolina 29910
Boiling Springs, South Carolina 29316
864-241-6251
Charleston, South Carolina 29425
Easley, South Carolina 29640
Gaffney, South Carolina 29341
Georgetown, South Carolina 29440
Greenville, South Carolina 29601
Greenville, South Carolina 29605
864-241-6251
Greenville, South Carolina 29605
864-241-6251
Greenville, South Carolina 29607
Greenville, South Carolina 29615
864-241-6251
Greer, South Carolina 29650
864-241-6251
Greer, South Carolina 29651
Hilton Head Island, South Carolina 29926
Hilton Head Island, South Carolina 29936
Rock Hill, South Carolina 29732
800-804-9376
Seneca, South Carolina 29672
864-241-6251
Spartanburg, South Carolina 29303
Union, South Carolina 29379
Rapid City, South Dakota 57701
Collierville, Tennessee 38017
Memphis, Tennessee 38120
Memphis, Tennessee 38120
Berlin Corners, Vermont 05602
802-225-5400
Fishersville, Virginia 22939
540-332-5960
Fredericksburg, Virginia 22408
Lynchburg, Virginia 24501
Richmond, Virginia 23298
Roanoke, Virginia 24033
540-981-7377
South Hill, Virginia 23970
Winchester, Virginia 22601
Bellevue, Washington 98004
Edmonds, Washington 98026
Issaquah, Washington 98029
Kennewick, Washington 99336
Port Townsend, Washington 98368
360-344-3091
Seattle, Washington 98112
Seattle, Washington 98122
Walla Walla, Washington 99362
Huntington, West Virginia 25701
Appleton, Wisconsin 54911
Ashland, Wisconsin 54806
Berlin, Wisconsin 54923
Brookfield, Wisconsin 53045
Burlington, Wisconsin 53105
Chippewa Falls, Wisconsin 54729
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
855-776-0015
Franklin, Wisconsin 53132
Germantown, Wisconsin 53022
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54303
Hayward, Wisconsin 54843
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
855-776-0015
Ladysmith, Wisconsin 54848
Madison, Wisconsin 53792
Marinette, Wisconsin 54143
Marshfield, Wisconsin 54449
Mequon, Wisconsin 53097
Milwaukee, Wisconsin 53211
Milwaukee, Wisconsin 53215
Minocqua, Wisconsin 54548
Neenah, Wisconsin 54956
Neillsville, Wisconsin 54456
New London, Wisconsin 54961
New Richmond, Wisconsin 54017
Oconto Falls, Wisconsin 54154
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Rhinelander, Wisconsin 54501
Rice Lake, Wisconsin 54868
Shawano, Wisconsin 54166
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Spooner, Wisconsin 54801
Stevens Point, Wisconsin 54481
Stevens Point, Wisconsin 54482
Sturgeon Bay, Wisconsin 54235
Two Rivers, Wisconsin 54241
Waupaca, Wisconsin 54981
Wausau, Wisconsin 54401
877-405-6866
Wausau, Wisconsin 54401
Wauwatosa, Wisconsin 53226
Weston, Wisconsin 54476
Wisconsin Rapids, Wisconsin 54494
715-422-7718
Wisconsin Rapids, Wisconsin 54494
ManatÃ, PR, Puerto Rico 00674
(787) 621-4397
San Juan, PR, Puerto Rico 00927
(787) 919-7919
San Juan, Puerto Rico 00927
More Details
- Status
- Recruiting
- Sponsor
- Wake Forest University Health Sciences
Detailed Description
The objective of this study is to examine the association between cannabis and/or cannabinoid use and cancer-related symptoms assessed monthly for one year in adults newly diagnosed with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer who are planning or recently started to receive one or more systemic cancer directed therapies with chemotherapy and/or immune check point inhibitors (ICIs) targeting PD-1, PD-L1 or CTLA-4. Participants complete surveys and have their medical records reviewed on study.