A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
Purpose
The purpose of this study is to evaluate efficacy, safety and tolerability of s.c. ianalumab administered in participants with diffuse cutaneous systemic sclerosis relative to placebo
Condition
- Diffuse Cutaneous Systemic Sclerosis
Eligibility
- Eligible Ages
- Between 18 Years and 70 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Male and female participants >= 18 and =< 70 years (at the time of the screening visit). - Diagnosis of systemic sclerosis, as defined by the 2013 American College of Rheumatology/ European League Against Rheumatism (ACR/EULAR) classification criteria for SSc (van den Hoogen et al 2013) and meet the dcSSc subset classification according to LeRoy (LeRoy 1988) - Disease duration of =< 60 months (defined as time from the first non-Raynaud phenomenon manifestation, e.g., puffy hands, scleroderma, digital ulcers, arthralgia, dyspnea) - mRSS units of >= 15 and =< 45 at the time of the screening visit - Active disease that meets at least one of the following criteria at screening: - Disease duration of =< 18 months defined as time from the first non-Raynaud phenomenon manifestation - Increase in mRSS of >= 3 units compared with the most recent assessment performed within the previous 6 months - Involvement of one new body area and an increase in mRSS of >= 2 units compared with the most recent assessment performed within the previous 6 months - Involvement of two new body areas within the previous 6 months - Elevated acute phase reactants (ESR) >= 30 mm/hr or high-sensitivity C-reactive protein (hsCRP) >= 6 mg/L) - Presence of SSc-interstitial lung disease (ILD) and ATA autoantibody positivity - Modified EUSTAR disease activity index (mDAI) ≥ 2.5 - Participant must be positive for at least one of the following autoantibodies: - anti-topoisomerase I (ATA) (also known as anti-SCL-70) - anti-RNA polymerase III (anti-RNAP3) - anti-nuclear antibody (ANA) (≥ 1:80) Participants who are positive only for ANA (while being negative for both ATA /anti-RNAP3) will be limited to 30% of the overall randomized study population.
Exclusion Criteria
- Rheumatic disease other than dcSSc, including limited cutaneous disease (lcSSc) or sine scleroderma at the screening visit. Secondary Sjogren's disease and scleroderma myopathy are not exclusionary. - Positive anti-centromere antibody (ACA+) without positive ATA or anti-RNAP3 autoantibody result at the screening visit - Previous improvement (decrease) in mRSS > 10 units - Pulmonary disease with FVC ≤ 50% of predicted or diffusing capacity of the lung for carbon monoxide (DLCO, corrected for hemoglobin) ≤ 40% of predicted at the screening visit - WHO Functional Class 3 or higher assessment for pulmonary arterial hypertension (PAH, as defined on right heart catheterization), receiving IV therapy for PAH or evidence of other moderately severe pulmonary disease - Participants treated with cyclophosphamide within 12 weeks prior to Baseline. - Prior use of a B-cell depleting therapy other than ianalumab (e.g., rituximab, other anti-CD20 mAb, anti-CD22 mAb, or anti-CD52 mAb) administered within 36 weeks prior to randomization, or as long as B cell count is less than the lower limit of normal or baseline value prior to receipt of B cell-depleting therapy (whichever is lower). - Treatment with biologic agents, such as intravenous immunoglobulin or monoclonal antibodies, including marketed drugs, within 12 weeks or 5 half-lives (whichever is longer) prior to baseline visit, unless explicitly allowed in inclusion criteria. - Treatment with any investigational agent within ≤ 4 weeks (or 5 half-lives of the investigational drug, whichever is longer) of the baseline visit. - Use of anti-fibrotic agents including colchicine, D-penicillamine, pirfenidone, or tyrosine kinase inhibitors (e.g., nintedanib, nilotinib, imatinib, dasatinib) in the 4 weeks prior to baseline visit. Patients with SSc-ILD requiring antifibrotics for management of ILD during the study, as per investigator judgement, should be excluded. - Previous treatment with chlorambucil, bone marrow transplantation or total lymphoid irradiation. - Women of childbearing potential, defined as all women physiologically capable of becoming pregnant from menarche until becoming post-menopausal, unless they are using highly effective methods of contraception (failure rate < 1% per year) while taking study treatment and for 6 months after stopping study treatment. Other protocol-defined inclusion/exclusion criteria may apply.
Study Design
- Phase
- Phase 2
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental VAY736 (Ianalumab) |
Treatment Period 1: Ianalumab subcutaneous (s.c.) injection as defined in the protocol Treatment Period 2: Open-label (OL) Ianalumab subcutaneous (s.c.) injection as defined in the protocol |
|
|
Placebo Comparator Placebo |
Treatment Period 1: Placebo to Ianalumab subcutaneous (s.c.) injection as defined in the protocol Treatment Period 2: Open-label (OL) Ianalumab subcutaneous (s.c.) injection as defined in the protocol |
|
Recruiting Locations
Arizona Arthritis and Rheumatology Research PLLC
Mesa, Arizona 85202
Mesa, Arizona 85202
Clinical Res Of W Florida
Clearwater, Florida 33765
Clearwater, Florida 33765
GNP Research
Cooper City, Florida 33024
Cooper City, Florida 33024
IRIS Research and Development
Plantation, Florida 33324
Plantation, Florida 33324
Sarasota Arthritis Res Ctr
Sarasota, Florida 34239
Sarasota, Florida 34239
University of Chicago Hospitals
Chicago, Illinois 60637
Chicago, Illinois 60637
Uni Of Michigan Health System
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
Wayne State University
Detroit, Michigan 48201
Detroit, Michigan 48201
Clinical Research Inst of MI
Saint Clair Shores, Michigan 48081
Saint Clair Shores, Michigan 48081
Hospital for Special Surgery
New York, New York 10021
New York, New York 10021
West Tennessee Research Institute
Jackson, Tennessee 38305
Jackson, Tennessee 38305
Arthritis and Rheumatology Ins
Allen, Texas 75035
Allen, Texas 75035
Prolato Clinical Research Center
Houston, Texas 77054
Houston, Texas 77054
More Details
- Status
- Recruiting
- Sponsor
- Novartis Pharmaceuticals
Detailed Description
The study consists of the following periods: - Screening Period, with a duration of up to 6 weeks; - Treatment Period 1, with a duration of 52 weeks; - Treatment Period 2 (Open-label treatment), with a duration of 52 weeks; - Post-treatment Follow-up Period, with a duration of at least 20 weeks post last dose and up to 2 years.