Sleep Restriction and Parental History of Hypertension
Purpose
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Condition
- Hypertension
Eligibility
- Eligible Ages
- Between 18 Years and 35 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Healthy adults aged 18-35 years - Absence of any significant medical or psychiatric disease (as per the investigators' judgment) - Nonsmoker - Nonpregnant - History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping) - Hypertension status information available for both biological parents - Ability to understand study procedures and to comply with them for the entire length of the study - Ability to understand English and provide informed consent
Exclusion Criteria
- Age <18 or >35 years - Body mass index <18.5 or ≥30 kg/m2 - Pregnant or lactating - Unable to determine history of HTN in participant's biological parents or subject being adopted - Use of tobacco, vaping, marijuana products or other drugs - Excessive caffeine consumption (>400 mg/day) - Excessive alcohol consumption (>7 drinks/week for women, >14 drinks/week for men) - Office SBP/DBP ≥130/80 mmHg - Daytime ambulatory SBP/DBP ≥130/80 mmHg - Fasting glucose ≥126 mg/dl - Glomerular filtration rate <60 mL/min/BSA - History of significant medical or psychiatric disorders (as per the investigators' judgment) - Regular use of prescription medications other than contraceptives - Use of melatonin supplements or any other over-the-counter sleep aid - Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale >10) - Moderate-to-severe insomnia (Insomnia Severity Index >14) - Restless leg syndrome (as per the Cambridge-Hopkins questionnaire) - Excessive daytime sleepiness (Epworth Sleepiness Scale >15) - Extreme chronotype (Morningness-Eveningness Questionnaire >69 or <31) - Night shift work - Ongoing participation in other research studies (as per the investigators' judgment) - Any other medical, geographic, or social factor making study participation impractical - Not English-speaking and/or inability to provide informed consent - Exclusionary for blood draws: hemoglobin <11.6 g/dL in women / <13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover Assignment
- Primary Purpose
- Other
- Masking
- Double (Investigator, Outcomes Assessor)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Study Sequence AB |
Sleep restriction condition in the first period and normal sleep condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase. |
|
|
Experimental Study Sequence BA |
Normal sleep condition in the first period and sleep restriction condition in the second period. Each period will consist of a 10-day inpatient visit comprising a 3-day/2-night baseline, followed by a 5-day/5-night experimental phase, and a 2-day/2-night recovery phase. |
|
Recruiting Locations
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
More Details
- Status
- Recruiting
- Sponsor
- Mayo Clinic