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Purpose

This study aims to assess whether to describe the effects of the administration of nasal high flow (NHF) at 70 liters per minute (L/min) in a 6-Minute Walk Test (6-MWT) among Chronic Obstructive Pulmonary Disease (COPD) patients and to characterize the association between self-reported dyspnea with and without NHF at 70 L/min following a 6-MWT.

Condition

Eligibility

Eligible Ages
Between 18 Years and 100 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Able to consent - Age 18 years or older - Diagnosis of COPD - Ability to ambulate without assistance - Use of low-flow nasal cannula ≤ 4 L/min or no supplemental oxygen (O2) at all

Exclusion Criteria

  • Pregnancy - Being on bedrest - Inability to consent or cooperate with the study - Using of > 4 L/min of supplemental O2 or requiring non-invasive ventilation during the daytime - Hemodynamic instability (resting heart rate > 130/minute, systolic blood pressure of ≤ 90 mmHg or ≥ 180 mmHg) - Metal implants in the thoracic regions (pacemakers, Automatic Implantable Cardioverter Defibrillator (AICD), plates, screws, rods, and disc replacements)

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Nasal High Flow Cannula 		Nasal High Flow cannula at 70 liters per minute for 30 minutes. Given that this is a cross-over study, participants on this arm will be then crossed over to Nasal Low Flow Cannula at less than or equal to 4 liters per minute with supplemental oxygen for 30 minutes
  • Device: Nasal High Flow Cannula
    High flow nasal cannula is a device that provides heated and humidified high flow gases. In-person. Depending on participant's availability, up to 6 times
  • Device: Nasal Low Flow Cannula
    Low flow nasal cannula is a device that provides low flow gases. In-person. Depending on participant's availability, up to 6 times
Active Comparator
Nasal Low Flow Cannula 		Low Flow Nasal Cannula at less than or equal to 4 liters per minute with supplemental oxygen at patient's baseline for 30 minutes. Given that this is a cross-over study, participants on this arm will be then crossed over to High Flow Cannula at 70 liters per minute for 30 minutes
  • Device: Nasal High Flow Cannula
    High flow nasal cannula is a device that provides heated and humidified high flow gases. In-person. Depending on participant's availability, up to 6 times
  • Device: Nasal Low Flow Cannula
    Low flow nasal cannula is a device that provides low flow gases. In-person. Depending on participant's availability, up to 6 times

Recruiting Locations

University of Miami
Miami, Florida 33136
Contact:
Saramaria Afanador Castiblanco, M.D.
3052432568
saramaria.afanador@miami.edu

More Details

Status
Recruiting
Sponsor
University of Miami

Study Contact

Saramaria Afanador Castiblanco, M.D.
305-243-2568
saramaria.afanador@miami.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.