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Purpose

EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 100 Years
Eligible Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • 18-100 years old - Biologically born female - Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group) - No cancer diagnosis (Arm 2-health control)

Exclusion Criteria

  • less than 18 years of age - Biologically born male - Incarcerated at the time of participation

Study Design

Phase
Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Arm Groups

ArmDescriptionAssigned Intervention
EGFR Positive Lung Cancer Subjects diagnosed with EGFR positive lung cancer
  • Other: blood draw
    A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
  • Other: Gene sequencing
    Subjects will have their DNA sequenced within and around the EGFR gene.
Healthy Subjects Subjects who do not have a cancer diagnosis
  • Other: blood draw
    A 10ml Blood sample will be taken and used to sequence the EGFR gene and surrounding DNA.
  • Other: Gene sequencing
    Subjects will have their DNA sequenced within and around the EGFR gene.

Recruiting Locations

Our Lady of the Lake Regional Medical Center
Baton Rouge, Louisiana 70808

More Details

Status
Recruiting
Sponsor
Our Lady of the Lake Hospital

Study Contact

Cynthia Knox, MBA
225-765-3344
Cynthia.Knox@fmolhs.org

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.