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Purpose

For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.

Condition

Eligibility

Eligible Ages
Between 25 Years and 60 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Have signed the Informed Consent Form (ICF) - Aged 25 to 60 years, inclusive, at the time of signing the ICF - Confirmation of Huntington Disease (HD) gene expansion mutation carrier status - Confirmation of Total Functional Capacity (TFC) ≥9 and Total Motor Score (TMS) >6 within 12 months prior to signing the ICF - Ability to tolerate blood draws

Exclusion Criteria

  • None

Study Design

Phase
Study Type
Observational
Observational Model
Other
Time Perspective
Other

Arm Groups

ArmDescriptionAssigned Intervention
Participants Who Are Huntington Disease Gene Expansion Carriers

Recruiting Locations

Barrow Neurological Institute
Phoenix 5308655, Arizona 5551752 85013

University of South Florida
Tampa 4174757, Florida 4155751 33612

Beth Israel Deaconess Medical Center
Boston 4930956, Massachusetts 6254926 02215

University of Pittsburgh
Pittsburgh 5206379, Pennsylvania 6254927 15213

Vanderbilt University Medical Center
Nashville 4644585, Tennessee 4662168 37212

EvergreenHealth Investigational Drug Services
Kirkland 5799841, Washington 5815135 98034

More Details

Status
Recruiting
Sponsor
Hoffmann-La Roche

Study Contact

Reference Study ID Number: WE45491 https://forpatients.roche.com/
888-662-6728 (U.S. Only)
global-roche-genentech-trials@gene.com

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.