ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Purpose
This phase III trial compares 6 months of human epidermal growth factor receptor 2 (HER2)-targeted therapy to 12 months of HER2-targeted therapy for the treatment of HER2-positive (+) breast cancer in patients that had a pathologic complete response (pCR) after preoperative (neoadjuvant) chemotherapy with trastuzumab. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to a receptor protein called HER2. HER2 is found on some cancer cells. When trastuzumab or pertuzumab attach to HER2, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Giving 6 months of HER2-targeted therapy may work better than giving 12 months for the treatment of HER2+ breast cancer in patients that had a pCR after neoadjuvant chemotherapy with trastuzumab.
Conditions
- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Early Stage Breast Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients (females and males) with clinical stage T1c-T3 (or Tx) and nodal stage N0-N1 (except T3N1 tumors, which are not eligible) - Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Patients with residual isolated tumor cells at surgery are considered node-positive and are not eligible - HER2+ by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines. Central pathology review is not required. In cases where there were multiple tumor sites in breast/nodes that had HER2 testing at diagnosis, at least one site must have been HER2+ AND the treating investigator must feel it is in the patient's best interest to be treated as having HER2+ breast cancer - Known hormone receptor status as defined by ASCO/CAP guidelines. Estrogen receptor (ER) and progesterone receptor (PR) of any values are allowed. Hormone receptor positive status can be determined by either known positive ER or known positive PR status; hormone receptor negative status must be determined by both known negative ER and known negative PR - If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts (including the requirement that at least one biopsied site on each side must have been HER2+) - Age ≥ 18 years - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Patients must have received neoadjuvant chemotherapy in combination with trastuzumab with or without pertuzumab for a minimum of 12 weeks. All chemotherapy must have been completed preoperatively - Patient must complete a minimum of 12 weeks of coverage with trastuzumab and a maximum of 24 weeks in the combined neoadjuvant and adjuvant setting prior to trial registration. Trastuzumab may have been administered either weekly or once every 3 weeks (q3weeks). (For purposes of this eligibility criterion, a single dose of q3week trastuzumab would provide 3 weeks of coverage; a single dose of once a week (q1week) trastuzumab would provide 1 week of coverage. If a q3week dose of trastuzumab were administered and then the subsequent dose was delayed for any period of time, that would still count as 3 weeks of coverage.) - Administration of endocrine therapy for treatment of this breast cancer is allowed prior to trial registration. If a patient received prior breast cancer endocrine therapy (eg tamoxifen or aromatase inhibitor) for DCIS or preventive indication, and endocrine therapy is indicated for treatment of their current breast cancer, then prior endocrine therapy must have been stopped > 12 months prior to registration on this protocol - No use of investigational anti-cancer agents at time of registration - Patient must register within 14 weeks of final surgery - Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows: - Breast surgery: Total mastectomy with grossly negative margins (in the opinion of the surgeon there is no disease grossly at the margins) or breast-conserving surgery with histologically negative margins (no ink on tumor, including DCIS) unless those margins are anterior at the skin or posterior at the chest wall and no additional margin re-excision can be performed - Lymph node surgery: Lymph node surgery must have been performed and can include sentinel lymph node biopsy, targeted axillary dissection, or axillary dissection, at the discretion of the breast surgeon - Adequate radiation: Patients who completed breast-conserving surgery (i.e. lumpectomy) must have received or plan to receive adjuvant radiation. If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible. Patients for whom radiotherapy would be recommended for breast cancer treatment but for whom it is contraindicated because of medical reasons (e.g., connective tissue disorder or prior ipsilateral breast radiation) are not eligible - Adjuvant radiation can be given on study, and in this case is encouraged to be given concurrently with adjuvant HER2-directed therapy, per investigator discretion - Targeting of the regional nodal basins will be at treating investigator discretion - Not pregnant and not nursing, because this study involves agents with known teratogenic potential. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test should be performed prior to receiving HER2-directed therapy according to local standard practice - Adequate hepatic, renal and bone marrow function to receive adjuvant HER2-directed therapy in the opinion of the treating investigator. There are no specific required laboratory values for eligibility - No stage IV (metastatic) breast cancer - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial - No history of any prior (ipsilateral [ipsi-] or contralateral) invasive breast cancer. Prior DCIS is allowed - No evidence of recurrent disease following preoperative therapy and surgery - Patients living with HIV who are healthy and deemed by their medical team to have a low risk of AIDS-related illnesses are included in this trial. Patients with Hepatitis B or Hepatitis C virus who are healthy and deemed by their medical team to meet all other enrollment criteria are included in this trial. - Patients with inadequate cardiac function on most recent assessment of left ventricular ejection fraction (LVEF) are not eligible for this trial. Inadequate cardiac function is defined as LVEF < 50% on echocardiogram (echo) or multiple-gated acquisition (MUGA) - No history of grade 3 or 4 toxicity related to trastuzumab. If pertuzumab is planned to be given on trial, patient must also have no history of grade 3-4 toxicity related to pertuzumab - No contraindication to receipt of further HER2-directed therapy - No patients with severe, uncontrolled systemic disease that may interfere with planned trial therapy.
Exclusion Criteria
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm 1 (12-month adjuvant therapy) |
Patients receive trastuzumab IV or SC on day 1 of each cycle. Patients may also receive pertuzumab IV or SC, at the discretion of the treating investigator, on day 1 of each cycle. Cycles repeat every 21 days for up to 17 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo ECHO or MUGA as well as mammography, ultrasound, or MRI throughout the trial. Patients may also optionally undergo blood and tissue sample collection throughout the trial. |
|
|
Experimental Arm 2 (6-month adjuvant therapy) |
Patients receive trastuzumab IV or SC on day 1 of each cycle. Patients may also receive pertuzumab IV or SC, at the discretion of the treating investigator, on day 1 of each cycle. Cycles repeat every 21 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo ECHO or MUGA as well as mammography, ultrasound, or MRI throughout the trial. Patients may also optionally undergo blood and tissue sample collection throughout the trial. |
|
Recruiting Locations
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Enloe Medical Center
Chico 5336269, California 5332921 95926
Chico 5336269, California 5332921 95926
Contact:
Site Public Contact
530-332-4700
Site Public Contact
530-332-4700
Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Kaiser Permanente Fresno Orchard Plaza
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
Contact:
Site Public Contact
833-574-2273
Site Public Contact
833-574-2273
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Irvine 5359777, California 5332921 92612
Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Modesto 5373900, California 5332921 95356
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Sacramento 5389489, California 5332921 95814
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
San Jose 5392171, California 5332921 95119
Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
San Leandro 5392263, California 5332921 94577
Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
San Rafael 5392567, California 5332921 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Santa Clara 5393015, California 5332921 95051
Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee 5403676, California 5332921 96161
Truckee 5403676, California 5332921 96161
Contact:
Site Public Contact
530-582-6450
Site Public Contact
530-582-6450
Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Walnut Creek 5406990, California 5332921 94596
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
UCI Health - Yorba Linda
Yorba Linda 5410902, California 5332921 92886
Yorba Linda 5410902, California 5332921 92886
Shaw Cancer Center
Edwards 5420885, Colorado 5417618 81632
Edwards 5420885, Colorado 5417618 81632
Contact:
Site Public Contact
970-569-7429
Site Public Contact
970-569-7429
Smilow Cancer Hospital-Derby Care Center
Derby 4832745, Connecticut 4831725 06418
Derby 4832745, Connecticut 4831725 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield 4834157, Connecticut 4831725 06824
Fairfield 4834157, Connecticut 4831725 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury 4835003, Connecticut 4831725 06033
Glastonbury 4835003, Connecticut 4831725 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich 4835395, Connecticut 4831725 06830
Greenwich 4835395, Connecticut 4831725 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford 4835512, Connecticut 4831725 06437
Guilford 4835512, Connecticut 4831725 06437
Smilow Cancer Hospital Care Center at Saint Francis
Hartford 4835797, Connecticut 4831725 06105
Hartford 4835797, Connecticut 4831725 06105
Yale University
New Haven 4839366, Connecticut 4831725 06520
New Haven 4839366, Connecticut 4831725 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven 4839704, Connecticut 4831725 06473
North Haven 4839704, Connecticut 4831725 06473
Smilow Cancer Hospital Care Center at Long Ridge
Stamford 4843564, Connecticut 4831725 06902
Stamford 4843564, Connecticut 4831725 06902
Smilow Cancer Hospital-Torrington Care Center
Torrington 4844309, Connecticut 4831725 06790
Torrington 4844309, Connecticut 4831725 06790
Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725 06611
Trumbull 4844459, Connecticut 4831725 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury 4845193, Connecticut 4831725 06708
Waterbury 4845193, Connecticut 4831725 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725 06385
Waterford 8480031, Connecticut 4831725 06385
Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Millville 4143696, Delaware 4142224 19967
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Rehoboth Beach 4144284, Delaware 4142224 19971
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106 20007
Washington D.C. 4140963, District of Columbia 4138106 20007
Contact:
Site Public Contact
202-444-2223
Site Public Contact
202-444-2223
MedStar Washington Hospital Center
Washington D.C. 4140963, District of Columbia 4138106 20010
Washington D.C. 4140963, District of Columbia 4138106 20010
Contact:
Site Public Contact
202-877-8839
Site Public Contact
202-877-8839
Morton Plant Hospital
Clearwater 4151316, Florida 4155751 33756
Clearwater 4151316, Florida 4155751 33756
Contact:
Site Public Contact
855-314-8646
Site Public Contact
855-314-8646
Jupiter Medical Center
Jupiter 4160610, Florida 4155751 33458
Jupiter 4160610, Florida 4155751 33458
Sacred Heart Hospital
Pensacola 4168228, Florida 4155751 32504
Pensacola 4168228, Florida 4155751 32504
South Florida Baptist Hospital
Plant City 4168773, Florida 4155751 33563
Plant City 4168773, Florida 4155751 33563
Saint Anthony's Hospital Cancer Care Center
St. Petersburg 4171563, Florida 4155751 33705
St. Petersburg 4171563, Florida 4155751 33705
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751 33607
Tampa 4174757, Florida 4155751 33607
Winter Haven Hospital
Winter Haven 4178552, Florida 4155751 33881
Winter Haven 4178552, Florida 4155751 33881
Kaiser Permanente Moanalua Medical Center
Honolulu 5856195, Hawaii 5855797 96819
Honolulu 5856195, Hawaii 5855797 96819
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Boise 5586437, Idaho 5596512 83712
Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Coeur d'Alene 5589173, Idaho 5596512 83814
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Fruitland 5593708, Idaho 5596512 83619
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Meridian 5600685, Idaho 5596512 83642
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Nampa 5601933, Idaho 5596512 83687
Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
Post Falls 5604353, Idaho 5596512 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512 83864
Sandpoint 5606401, Idaho 5596512 83864
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Carterville 4235311, Illinois 4896861 62918
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Northwestern University
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60611
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Chicago 4887398, Illinois 4896861 60637
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
UChicago Medicine AdventHealth Cancer Institute Hinsdale
Hinsdale 4896012, Illinois 4896861 60521
Hinsdale 4896012, Illinois 4896861 60521
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
New Lenox 4903535, Illinois 4896861 60451
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
UChicago Medicine Northwest Indiana
Crown Point 4919451, Indiana 4921868 46307
Crown Point 4919451, Indiana 4921868 46307
Mary Greeley Medical Center
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Ames
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
McFarland Clinic - Boone
Boone 4849051, Iowa 4862182 50036
Boone 4849051, Iowa 4862182 50036
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
Saint Anthony Regional Hospital
Carroll 4850478, Iowa 4862182 51401
Carroll 4850478, Iowa 4862182 51401
Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727
Site Public Contact
515-241-6727
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-282-2200
Site Public Contact
515-282-2200
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
McFarland Clinic - Trinity Cancer Center
Fort Dodge 4857486, Iowa 4862182 50501
Fort Dodge 4857486, Iowa 4862182 50501
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
UI Healthcare Mission Cancer and Blood - Fort Dodge
Fort Dodge 4857486, Iowa 4862182 50501
Fort Dodge 4857486, Iowa 4862182 50501
McFarland Clinic - Jefferson
Jefferson 4862482, Iowa 4862182 50129
Jefferson 4862482, Iowa 4862182 50129
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Marshalltown
Marshalltown 4866371, Iowa 4862182 50158
Marshalltown 4866371, Iowa 4862182 50158
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
UI Healthcare Mission Cancer and Blood - Pella
Pella 4870915, Iowa 4862182 50219
Pella 4870915, Iowa 4862182 50219
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
The Iowa Clinic PC
West Des Moines 4881346, Iowa 4862182 50266
West Des Moines 4881346, Iowa 4862182 50266
Contact:
Site Public Contact
515-875-9815
Site Public Contact
515-875-9815
Cancer Center of Kansas - Chanute
Chanute 4269392, Kansas 4273857 66720
Chanute 4269392, Kansas 4273857 66720
Cancer Center of Kansas - Dodge City
Dodge City 5445298, Kansas 4273857 67801
Dodge City 5445298, Kansas 4273857 67801
Cancer Center of Kansas - El Dorado
El Dorado 4270863, Kansas 4273857 67042
El Dorado 4270863, Kansas 4273857 67042
Cancer Center of Kansas-Independence
Independence 4273359, Kansas 4273857 67301
Independence 4273359, Kansas 4273857 67301
Cancer Center of Kansas-Kingman
Kingman 4273978, Kansas 4273857 67068
Kingman 4273978, Kansas 4273857 67068
Cancer Center of Kansas-Liberal
Liberal 5445820, Kansas 4273857 67905
Liberal 5445820, Kansas 4273857 67905
Cancer Center of Kansas - Newton
Newton 4276248, Kansas 4273857 67114
Newton 4276248, Kansas 4273857 67114
The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Olathe 4276614, Kansas 4273857 66061
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Overland Park 4276873, Kansas 4273857 66210
University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857 66211
Overland Park 4276873, Kansas 4273857 66211
Cancer Center of Kansas - Parsons
Parsons 4277011, Kansas 4273857 67357
Parsons 4277011, Kansas 4273857 67357
Cancer Center of Kansas - Pratt
Pratt 4277752, Kansas 4273857 67124
Pratt 4277752, Kansas 4273857 67124
Cancer Center of Kansas - Salina
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
Cancer Center of Kansas - Wellington
Wellington 4281386, Kansas 4273857 67152
Wellington 4281386, Kansas 4273857 67152
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Westwood 4281639, Kansas 4273857 66205
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita 4281730, Kansas 4273857 67208
Wichita 4281730, Kansas 4273857 67208
Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
Cancer Center of Kansas - Wichita
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
Cancer Center of Kansas - Winfield
Winfield 4281897, Kansas 4273857 67156
Winfield 4281897, Kansas 4273857 67156
The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-562-3429
Site Public Contact
502-562-3429
UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925 40245
Louisville 4299276, Kentucky 6254925 40245
University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987 70121
New Orleans 4335045, Louisiana 4331987 70121
Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
UM Upper Chesapeake Hematology and Oncology - Aberdeen
Aberdeen 4346913, Maryland 4361885 21001
Aberdeen 4346913, Maryland 4361885 21001
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885 21204
Baltimore 4347778, Maryland 4361885 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore 4347778, Maryland 4361885 21237
Baltimore 4347778, Maryland 4361885 21237
Contact:
Site Public Contact
443-777-7364
Site Public Contact
443-777-7364
MedStar Good Samaritan Hospital
Baltimore 4347778, Maryland 4361885 21239
Baltimore 4347778, Maryland 4361885 21239
UM Upper Chesapeake Medical Center
Bel Air 4348240, Maryland 4361885 21014
Bel Air 4348240, Maryland 4361885 21014
Contact:
Site Public Contact
443-643-3010
Site Public Contact
443-643-3010
UPMC Western Maryland
Cumberland 4352681, Maryland 4361885 21502
Cumberland 4352681, Maryland 4361885 21502
Contact:
Site Public Contact
240-964-1400
Site Public Contact
240-964-1400
MedStar Montgomery Medical Center
Olney 4364537, Maryland 4361885 20832
Olney 4364537, Maryland 4361885 20832
Contact:
Site Public Contact
855-546-1944
Site Public Contact
855-546-1944
Bronson Battle Creek
Battle Creek 4985153, Michigan 5001836 49017
Battle Creek 4985153, Michigan 5001836 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Hematology Oncology Consultants-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Newland Medical Associates-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
OSF Saint Francis Hospital and Medical Group
Escanaba 4992232, Michigan 5001836 49829
Escanaba 4992232, Michigan 5001836 49829
Cancer Hematology Centers - Flint
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Lansing 4998830, Michigan 5001836 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Muskegon 5003132, Michigan 5001836 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores 5004005, Michigan 5001836 49444
Norton Shores 5004005, Michigan 5001836 49444
Hope Cancer Center
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Newland Medical Associates-Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Corewell Health Reed City Hospital
Reed City 5006946, Michigan 5001836 49677
Reed City 5006946, Michigan 5001836 49677
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Traverse City 5012495, Michigan 5001836 49684
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Sanford Thief River Falls Medical Center
Thief River Falls 5049970, Minnesota 5037779 56701
Thief River Falls 5049970, Minnesota 5037779 56701
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Sanford Cancer Center Worthington
Worthington 5053460, Minnesota 5037779 56187
Worthington 5053460, Minnesota 5037779 56187
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Mercy Oncology and Hematology - Clayton-Clarkson
Ballwin 4375663, Missouri 4398678 63011
Ballwin 4375663, Missouri 4398678 63011
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
University Health Truman Medical Center
Kansas City 4393217, Missouri 4398678 64108
Kansas City 4393217, Missouri 4398678 64108
Contact:
Site Public Contact
816-404-4375
Site Public Contact
816-404-4375
University of Kansas Cancer Center - Briarcliff
Kansas City 4393217, Missouri 4398678 64116
Kansas City 4393217, Missouri 4398678 64116
Contact:
Site Public Contact
913-588-3671
Site Public Contact
913-588-3671
University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Kansas City 4393217, Missouri 4398678 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Lee's Summit 4394870, Missouri 4398678 64064
Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Osage Beach 4402040, Missouri 4398678 65065
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
Anaconda 5637146, Montana 5667009 59711
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Billings 5640350, Montana 5667009 59101
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Community Medical Center
Missoula 5666639, Montana 5667009 59804
Missoula 5666639, Montana 5667009 59804
Jefferson Cherry Hill Hospital
Cherry Hill 4501198, New Jersey 5101760 08002
Cherry Hill 4501198, New Jersey 5101760 08002
Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Sewell 4504048, New Jersey 5101760 08080
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Chapel Hill 4460162, North Carolina 4482348 27599
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348 28204
Charlotte 4460243, North Carolina 4482348 28204
Margaret R Pardee Memorial Hospital
Hendersonville 4470592, North Carolina 4482348 28791
Hendersonville 4470592, North Carolina 4482348 28791
Novant Health Cancer Institute - Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Huntersville 4472370, North Carolina 4482348 28078
Novant Health Cancer Institute - Kernersville
Kernersville 4474221, North Carolina 4482348 27284
Kernersville 4474221, North Carolina 4482348 27284
Novant Health Cancer Institute - Matthews
Matthews 4478334, North Carolina 4482348 28105
Matthews 4478334, North Carolina 4482348 28105
Novant Health Cancer Institute - Mooresville
Mooresville 4480125, North Carolina 4482348 28117
Mooresville 4480125, North Carolina 4482348 28117
Novant Health Cancer Institute - Mount Airy
Mount Airy 4480378, North Carolina 4482348 27030
Mount Airy 4480378, North Carolina 4482348 27030
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst 4485272, North Carolina 4482348 28374
Pinehurst 4485272, North Carolina 4482348 28374
Novant Health Cancer Institute - Thomasville
Thomasville 4494942, North Carolina 4482348 27360
Thomasville 4494942, North Carolina 4482348 27360
Novant Health Forsyth Medical Center
Winston-Salem 4499612, North Carolina 4482348 27103
Winston-Salem 4499612, North Carolina 4482348 27103
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Canton 5149222, Ohio 5165418 44710
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati 4508722, Ohio 5165418 45219
Cincinnati 4508722, Ohio 5165418 45219
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
University of Cincinnati Cancer Center-West Chester
West Chester 4520522, Ohio 5165418 45069
West Chester 4520522, Ohio 5165418 45069
Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Providence Hood River Memorial Hospital
Hood River 5731777, Oregon 5744337 97031
Hood River 5731777, Oregon 5744337 97031
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Newberg 5742726, Oregon 5744337 97132
Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Oregon City 5744253, Oregon 5744337 97045
Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Portland 5746545, Oregon 5744337 97210
Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Portland 5746545, Oregon 5744337 97213
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Portland 5746545, Oregon 5744337 97225
Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
UPMC-Heritage Valley Health System Beaver
Beaver 5179446, Pennsylvania 6254927 15009
Beaver 5179446, Pennsylvania 6254927 15009
UPMC Hillman Cancer Center at Butler Health System
Butler 5182534, Pennsylvania 6254927 16001
Butler 5182534, Pennsylvania 6254927 16001
WellSpan Medical Oncology and Hematology
Chambersburg 4557109, Pennsylvania 6254927 17201
Chambersburg 4557109, Pennsylvania 6254927 17201
Contact:
Site Public Contact
717-217-6020
Site Public Contact
717-217-6020
UPMC Hillman Cancer Center - Passavant - Cranberry
Cranberry Township 8643098, Pennsylvania 6254927 16066
Cranberry Township 8643098, Pennsylvania 6254927 16066
Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840
Site Public Contact
717-721-4840
UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Erie 5188843, Pennsylvania 6254927 16505
UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927 16121
Farrell 5189377, Pennsylvania 6254927 16121
Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg 5192726, Pennsylvania 6254927 17109
Harrisburg 5192726, Pennsylvania 6254927 17109
IRMC Cancer Center
Indiana 5194868, Pennsylvania 6254927 15701
Indiana 5194868, Pennsylvania 6254927 15701
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown 5195561, Pennsylvania 6254927 15901
Johnstown 5195561, Pennsylvania 6254927 15901
Contact:
Site Public Contact
814-534-4724
Site Public Contact
814-534-4724
Sechler Family Cancer Center
Lebanon 5197517, Pennsylvania 6254927 17042
Lebanon 5197517, Pennsylvania 6254927 17042
UPMC Cancer Center at UPMC McKeesport
McKeesport 5200499, Pennsylvania 6254927 15132
McKeesport 5200499, Pennsylvania 6254927 15132
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Mechanicsburg 5200657, Pennsylvania 6254927 17050
UPMC Hillman Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Monroeville 5201734, Pennsylvania 6254927 15146
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania 6254927 15642
N. Huntingdon, Pennsylvania 6254927 15642
UPMC Hillman Cancer Center - New Castle
New Castle 5203127, Pennsylvania 6254927 16105
New Castle 5203127, Pennsylvania 6254927 16105
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Philadelphia 4560349, Pennsylvania 6254927 19107
Jefferson Torresdale Hospital
Philadelphia 4560349, Pennsylvania 6254927 19114
Philadelphia 4560349, Pennsylvania 6254927 19114
UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811
Site Public Contact
412-647-2811
UPMC-Saint Margaret
Pittsburgh 5206379, Pennsylvania 6254927 15215
Pittsburgh 5206379, Pennsylvania 6254927 15215
Contact:
Site Public Contact
412-784-4900
Site Public Contact
412-784-4900
UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh 5206379, Pennsylvania 6254927 15243
Pittsburgh 5206379, Pennsylvania 6254927 15243
Contact:
Site Public Contact
412-502-3920
Site Public Contact
412-502-3920
UPMC Cancer Center at UPMC Northwest
Seneca 5211432, Pennsylvania 6254927 16346
Seneca 5211432, Pennsylvania 6254927 16346
Contact:
Site Public Contact
814-676-7900
Site Public Contact
814-676-7900
UPMC Cancer Center-Uniontown
Uniontown 4561859, Pennsylvania 6254927 15401
Uniontown 4561859, Pennsylvania 6254927 15401
UPMC Cancer Center-Washington
Washington 5218069, Pennsylvania 6254927 15301
Washington 5218069, Pennsylvania 6254927 15301
UPMC West Mifflin-Cancer Center Jefferson
West Mifflin 5218802, Pennsylvania 6254927 15122
West Mifflin 5218802, Pennsylvania 6254927 15122
Contact:
Site Public Contact
412-653-8100
Site Public Contact
412-653-8100
Divine Providence Hospital
Williamsport 5219585, Pennsylvania 6254927 17754
Williamsport 5219585, Pennsylvania 6254927 17754
Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Willow Grove 5219619, Pennsylvania 6254927 19090
Cancer Care Associates of York
York 4562407, Pennsylvania 6254927 17403
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
717-741-9229
Site Public Contact
717-741-9229
WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
Smilow Cancer Hospital Care Center - Westerly
Westerly 5225631, Rhode Island 5224323 02891
Westerly 5225631, Rhode Island 5224323 02891
Prisma Health Cancer Institute - Spartanburg
Boiling Springs 4571805, South Carolina 4597040 29316
Boiling Springs 4571805, South Carolina 4597040 29316
Prisma Health Cancer Institute - Easley
Easley 4577263, South Carolina 4597040 29640
Easley 4577263, South Carolina 4597040 29640
Prisma Health Cancer Institute - Butternut
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Eastside
Greenville 4580543, South Carolina 4597040 29615
Greenville 4580543, South Carolina 4597040 29615
Prisma Health Cancer Institute - Greer
Greer 4580599, South Carolina 4597040 29650
Greer 4580599, South Carolina 4597040 29650
Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Seneca 4595346, South Carolina 4597040 29672
Lexington Medical Center
West Columbia 4600541, South Carolina 4597040 29169
West Columbia 4600541, South Carolina 4597040 29169
Rapid City Regional Hospital
Rapid City 5768233, South Dakota 5769223 57701
Rapid City 5768233, South Dakota 5769223 57701
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Centra Alan B Pearson Regional Cancer Center
Lynchburg 4771075, Virginia 6254928 24501
Lynchburg 4771075, Virginia 6254928 24501
Bon Secours Memorial Regional Medical Center
Mechanicsville 4772566, Virginia 6254928 23116
Mechanicsville 4772566, Virginia 6254928 23116
Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Midlothian 4772943, Virginia 6254928 23114
Bon Secours Saint Mary's Hospital
Richmond 4781708, Virginia 6254928 23226
Richmond 4781708, Virginia 6254928 23226
Virginia Cancer Institute
Richmond 4781708, Virginia 6254928 23229
Richmond 4781708, Virginia 6254928 23229
VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928 23235
Richmond 4781708, Virginia 6254928 23235
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Richmond 4781708, Virginia 6254928 23298
VCU Community Memorial Health Center
South Hill 4786619, Virginia 6254928 23970
South Hill 4786619, Virginia 6254928 23970
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Vancouver 5814616, Washington 5815135 98684
Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850 25701
Huntington 4809537, West Virginia 4826850 25701
Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Antigo 5244010, Wisconsin 5279468 54409
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Green Bay 5254962, Wisconsin 5279468 54303
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Madison 5261457, Wisconsin 5279468 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Aspirus Medford Hospital
Medford 5262475, Wisconsin 5279468 54451
Medford 5262475, Wisconsin 5279468 54451
Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100
Site Public Contact
262-257-5100
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666
Site Public Contact
414-805-3666
Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468 54154
Oconto Falls 5265522, Wisconsin 5279468 54154
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Rhinelander 5268720, Wisconsin 5279468 54501
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan Physicians Group
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Stevens Point 5274644, Wisconsin 5279468 54481
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
Doctors Cancer Center
Manatí 4566137, Puerto Rico 00674
Manatí 4566137, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
Centro Comprensivo de Cancer de UPR
San Juan 4568127, Puerto Rico 00927
San Juan 4568127, Puerto Rico 00927
PROncology
San Juan 4568127, Puerto Rico 00927
San Juan 4568127, Puerto Rico 00927
San Juan City Hospital
San Juan 4568127, Puerto Rico 00936
San Juan 4568127, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296
Site Public Contact
787-763-1296
More Details
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
The primary and secondary objectives of the study: PRIMARY OBJECTIVES: I. To evaluate whether 6 months of combined neoadjuvant (neo)/adjuvant HER2 blockade results in a non-inferior recurrence-free survival (RFS) compared to 12 months of combined neo/adjuvant HER2 blockade, in patients with early stage HER2+ breast cancer who achieve pCR after neoadjuvant chemotherapy with HER2 blockade. II. To compare the Functional Assessment of Cancer Therapy-Breast (FACT-B) total score at 12 months between patients randomized to receive 6 months versus 12 months of combined neo/adjuvant HER2 blockade. (Quality of life) SECONDARY OBJECTIVES: I. Secondary objectives are to evaluate whether 6 months compared to 12 months results in differences for the following: Ia. Grade 3 or higher adverse event (AE) rates; Ib. Overall survival (OS); Ic. Locoregional recurrence (LRR, both isolated LRR as first events, and LRR events simultaneous with distant metastasis [DM]) incidence; Id. RFS for key subgroups: baseline stage, hormone receptor (HR) status, neoadjuvant chemotherapy backbone, and dual versus single HER2 blockade in the adjuvant setting; Ie. Time to central nervous system (CNS) recurrence (both isolated CNS recurrence as first events, and CNS recurrence events simultaneous with distant metastasis and/or LRR). II. To compare the FACT-B total score at 18 months between patients randomized to receive 6 months versus 12 months of combined neo/adjuvant HER2 blockade. (Quality of life) III. To compare side effect bother as measured by the Functional Assessment of Cancer Therapy General Population 5 (FACT GP5) item at 12 months between patients randomized to receive 6 months versus 12 months of combined neo/adjuvant HER2 blockade. (Quality of life) IV. To compare specific patient-reported symptomatic adverse events (i.e. diarrhea, constipation, fatigue, and rash) as measured by the Patient Reported Outcomes-Common Terminology Criteria for Adverse Events (PRO-CTCAE) at 12 months between patients randomized to receive 6 months versus 12 months of combined neo/adjuvant HER2 blockade. (Quality of life) QUALITY OF LIFE EXPLORATORY OBJECTIVES: I. To examine the different FACT-B subscales at all other evaluable time points. II. To examine heterogeneity of treatment effects within subgroups defined by subcutaneous versus intravenous treatment delivery. OUTLINE: Patients are randomized to 1 of 2 arms. ARM 1: Patients receive trastuzumab intravenously (IV) or subcutaneously (SC) on day 1 of each cycle. Patients may also receive pertuzumab IV or SC, at the discretion of the treating investigator, on day 1 of each cycle. Cycles repeat every 21 days for up to 17 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo echocardiography (ECHO) or multigated acquisition (MUGA) as well as mammography, ultrasound, or magnetic resonance imaging (MRI) throughout the trial. Patients may also optionally undergo blood and tissue sample collection throughout the trial. ARM 2: Patients receive trastuzumab IV or SC on day 1 of each cycle. Patients may also receive pertuzumab IV or SC, at the discretion of the treating investigator, on day 1 of each cycle. Cycles repeat every 21 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo ECHO or MUGA as well as mammography, ultrasound, or MRI throughout the trial. Patients may also optionally undergo blood and tissue sample collection throughout the trial. After completion of study treatment, patients are followed up every 6 months for 5 years after registration or until recurrence and then annually for a total of 10 years after registration.