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Purpose

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

Conditions

Eligibility

Eligible Ages
Between 18 Years and 65 Years
Eligible Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • 18 and 65 years of age - free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

Exclusion Criteria

  • Known heart disease - other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening. - Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test. - Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response. - Current smokers, as well as individuals who regularly smoked within the past 3 years. - body mass index is ≥ 31 kg/m2.

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover Assignment
Primary Purpose
Basic Science
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Hot and Humid with simulated burns 		Individuals will be exposed to hot and humid conditions with a simulated burn injury.
  • Other: Simulated burn injury via application of absorbent and impermeable material over 60% of the body
    Simulated burn injury via application of absorbent and impermeable material over 60% of the body
No Intervention
Hot and Humid without simulated burns 		Individuals will be exposed to hot and humid conditions without a simulated burn injury.
Experimental
Hot and Dry with simulated burns 		Individuals will be exposed to hot and dry conditions with a simulated burn injury.
  • Other: Simulated burn injury via application of absorbent and impermeable material over 60% of the body
    Simulated burn injury via application of absorbent and impermeable material over 60% of the body
No Intervention
Hot and Dry without simulated burns 		Individuals will be exposed to hot and dry conditions without a simulated burn injury.

Recruiting Locations

Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas
Dallas, Texas 75231
Contact:
Erin M Harper, B.S.
214-345-4737
erin.harper2@utsouthwestern.edu

More Details

Status
Recruiting
Sponsor
University of Texas Southwestern Medical Center

Study Contact

Erin M Harper, B.S.
12143454737
erin.harper2@utsouthwestern.edu

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.